Calbindin immunoreactive neurones in Alzheimer-type dementia

  • Y. Ichimiya
  • H. Arai
  • R. Iizuka
  • P. C. Emson
  • C. Q. Mountjoy
Part of the Key Topics in Brain Research book series (KEYTOPICS)


An antibody to the calcium binding protein, calbindin D28k (CaBP), was used to study the number and size of CaBP immunoreactive (CaBP-Ir) neurones in the cerebral cortex and the nucleus basalis of Meynert (nbM) of postmortem human brains from controls and from patients with Alzheimer-type dementia (ATD).

Compared to the controls, the number and size of CaBP-Ir neurones in the cerebral cortex and the nbM were reduced in the ATD.

These findings suggest that CaBP containing neurones are damaged in ATD.


Nucleus Basalis Immunoreactive Neurone Postmortem Human Brain Normal Elderly Control ChAT Immunoreactivity 
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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • Y. Ichimiya
    • 1
  • H. Arai
    • 1
  • R. Iizuka
    • 1
  • P. C. Emson
    • 2
  • C. Q. Mountjoy
    • 3
  1. 1.Department of PsychiatryJuntendo University School of MedicineTokyoJapan
  2. 2.MRC GroupInstitute of Animal Physiology and Genetics ResearchBabrahamUK
  3. 3.Department of PsychiatryUniversity of CambridgeCambridgeUK

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