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Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer’s disease

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Book cover Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics

Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

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Summary

Cholinergic fibers and terminals were visualized, with a polyclonal antiserum to human choline-acetyltransferase (ChAT), in hippocampi of 6 patients with Alzheimer’s disease (AD) and 4 control brains. The densities of senile plaques (SP) and neurofibrillary tangles (NFT) differed significantly between subregions in the AD brains. In contrast, the significant loss of terminals in the AD brains was homogenous in CA4, CA1 and the subiculum and presumably not related to the densities of SP and NFT in these subregions.

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References

  • American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn. APA, Washington

    Google Scholar 

  • Bruce G, Wainer BH, Hersh LB (1985) Immunoaffinity purification of human choline acetyltransferase: comparison of the brain and placental enzymes. J Neurochem 45: 611–620

    Article  PubMed  CAS  Google Scholar 

  • Davies P (1979) Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res 171: 319–327

    Article  PubMed  CAS  Google Scholar 

  • Graybiel AM, Hirsch EC, Agid YA (1987) Differences in tyrosine-hydroxylaselike immunoreactivity characterize the mesostriatal innervation of striosomes and extrastriosomal matrix at maturity. Proc Natl Acad Sci 84: 303–307

    Article  PubMed  CAS  Google Scholar 

  • Khatchaturian ZS (1985) Diagnosis of Alzheimer’s disease. Conference report. Arch Neurol 42: 1097–1105

    Article  Google Scholar 

  • Mesulam M-M, Mufson EJ, Wainer BH, Levey AI (1983) Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10: 1185–1201

    Article  PubMed  CAS  Google Scholar 

  • Perry RH, Blessed G, Perry EK, Tomlinson BE (1980) Histochemical observations on cholinesterase activity in the brain of elderly normal and demented (Alzheimer-type) patients. Age Ageing 9: 9–16

    Article  PubMed  CAS  Google Scholar 

  • Ransmayr G, Cervera P, Hirsch E, Ruberg M, Hersh LB, Duyckaerts C, Hauw J-J, Delumeau C, Agid Y (1989) Choline-acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer’s disease. Neuroscience 32: 701–714

    Article  PubMed  CAS  Google Scholar 

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Author information

Author notes

  1. G. Ransmayr

    Present address: University Clinic of Neurology, Anichstraße 35, A-6020, Innsbruck, Austria

Authors and Affiliations

  1. INSERM U. 289, Hôpital de la Salpêtrière, Paris, France

    G. Ransmayr, P. Cervera, E. Hirsch, M. Ruberg & Prof. Y. Agid MD, PhD

  2. Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, USA

    L. B. Hersh

  3. Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpêtrière, Paris, France

    C. Duyckaerts & J.-J. Hauw

Authors
  1. G. Ransmayr
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  2. P. Cervera
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  3. E. Hirsch
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  4. M. Ruberg
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  5. L. B. Hersh
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  6. C. Duyckaerts
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  7. J.-J. Hauw
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  8. Prof. Y. Agid MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    Konrad Maurer , Peter Riederer  & Helmut Beckmann ,  & 

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© 1990 Springer-Verlag Wien

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Ransmayr, G. et al. (1990). Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer’s disease. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_17

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  • DOI: https://doi.org/10.1007/978-3-7091-3396-5_17

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82197-8

  • Online ISBN: 978-3-7091-3396-5

  • eBook Packages: Springer Book Archive

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