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Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer’s disease

  • G. Ransmayr
  • P. Cervera
  • E. Hirsch
  • M. Ruberg
  • L. B. Hersh
  • C. Duyckaerts
  • J.-J. Hauw
  • Y. Agid
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Cholinergic fibers and terminals were visualized, with a polyclonal antiserum to human choline-acetyltransferase (ChAT), in hippocampi of 6 patients with Alzheimer’s disease (AD) and 4 control brains. The densities of senile plaques (SP) and neurofibrillary tangles (NFT) differed significantly between subregions in the AD brains. In contrast, the significant loss of terminals in the AD brains was homogenous in CA4, CA1 and the subiculum and presumably not related to the densities of SP and NFT in these subregions.

Keywords

Senile Plaque Hippocampal Formation Control Brain Stratum Pyramidale Rostrocaudal Extent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • G. Ransmayr
    • 1
  • P. Cervera
    • 1
  • E. Hirsch
    • 1
  • M. Ruberg
    • 1
  • L. B. Hersh
    • 2
  • C. Duyckaerts
    • 3
  • J.-J. Hauw
    • 3
  • Y. Agid
    • 1
  1. 1.INSERM U. 289Hôpital de la SalpêtrièreParisFrance
  2. 2.Department of BiochemistryUniversity of Texas Health Science CenterDallasUSA
  3. 3.Laboratoire de Neuropathologie R. EscourolleHôpital de la SalpêtrièreParisFrance

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