Immunocytochemical and ultrastructural pathology of nerve cells in Alzheimer’s disease and related disorders
Neurofibrillary tangles in Alzheimer’s disease were analysed by light and electron microscopic immunocytochemistry using antibodies against cytoskeletal antigens and ubiquitin. Our studies indicate that the antigenicity of paired helical filaments is profoundly changed during the stages of tangle formation and maturation. In addition, tangle formation may lead to changes in other neuronal cytoskeletal elements. A comparison of Alzheimer neurofibrillary tangles with cytoplasmic fibrillary inclusions in other CNS diseases indicates that ubiquitin binding to abnormal proteins may be a common denominator of such cytopathological conditions.
KeywordsNeurofibrillary Tangle Alcian Blue Progressive Supranuclear Palsy Paired Helical Filament Antigenic Profile
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