Skip to main content
SpringerLink
Log in

Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease

  • Chapter
Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics

Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

  • 142 Accesses

Summary

Macaques develop age-associated cognitive/memory impairments as well as brain abnormalities (particularly senile plaques) similar to those occurring in the brains of older humans and individuals with Alzheimer’s disease (AD). Some of these abnormalities can be clarified by investigations of aged nonhuman primates. Brain tissues from animals (ranging in age from 4–35 years) were examined by RNA blotting techniques, in situ hybridization, immunoblotting, and immunocytochemistry. These approaches allowed analysis of the evolution of some of the structural/chemical alterations (formation of neurites, amyloid deposition, and neurofibrillary tangles [NFT]) that occur in these animals. These investigations have relevance for understanding some of the behavioral, neuropathological, and neurochemical abnormalities that occur in older humans and in individuals with AD.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC (1989) αl-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits. Neuroscience 32: 715–720

    Google Scholar 

  • Allsop D, Wong CW, Ikeda S-I, Landon M, Kidd M, Glenner GG (1988) Immunohistochemical evidence for the derivation of a peptide ligand from the amyloid β-protein precursor of Alzheimer disease. Proc Natl Acad Sci USA 85: 2790–2794

    Article  PubMed  CAS  Google Scholar 

  • Anderton BH, Breinburg D, Downes MJ, Green PJ, Tomlinson BE, Ulrich J, Wood JN, Kahn J (1982) Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature 298: 84–86

    Article  PubMed  CAS  Google Scholar 

  • Bahmanyar S, Higgins GA, Goldgaber D, Lewis DA, Morrison JH, Wilson MC, Shankar SK, Gajdusek DC (1987) Localization of amyloid β-protein messenger RNA in brains from patients with Alzheimer’s disease. Science 237: 77–79

    Article  PubMed  CAS  Google Scholar 

  • Brion JP, van den Bosch de Aguilar P, Flament-Durand J (1985) Senile dementia of the Alzheimer type: morphological and immunocytochemical studies. In: Traber J, Gispen WH (eds) Senile dementia of the Alzheimer type. Springer, Berlin Heidelberg New York Tokyo, pp 164–174

    Chapter  Google Scholar 

  • Casella JF, Flanagan MD, Lin S (1983) Cytochalasins: their use as tools in the investigation of actin polymerization in vivo and in vitro. In: DosRemedios CG, Barden JA (eds) Actin: structure and function in muscle and non-muscle cells. Academic Press, Sydney, pp 227–240

    Google Scholar 

  • Castano EM, Frangione B (1988) Biology of disease. Human amyloidosis, Alzheimer disease and related disorders. Lab Invest 58: 122–132

    Google Scholar 

  • Cohen ML, Go1de TE, Usiak MF, Younkin LH, Younkin SG (1988) In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimer disease. Proc Natl Acad Sci USA 85: 1227–1231

    Article  PubMed  CAS  Google Scholar 

  • Cork LC, Sternberger NH, Sternberger LA, Casanova MF, Strubie RG, Price DL (1986) Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer’s disease. J Neuropathol Exp Neurol 45: 56–64

    Article  PubMed  CAS  Google Scholar 

  • Cork LC, Walker LC, Price DL (1989) Neurofibrillary tangles and senile plaques in a cognitively impaired, aged nonhuman primate. J Neuropathol Exp Neurol 48: 378

    Article  Google Scholar 

  • Glenner GG (1983) Alzheimer’s disease: multiple cerebral amyloidosis. Biological aspects of Alzheimer’s disease. Banbury Rep 15: 137–144

    Google Scholar 

  • Goedert M (1987) Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer’s disease. EMBO J 6: 3627–3632

    PubMed  CAS  Google Scholar 

  • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease. Science 235: 877–880

    Article  PubMed  CAS  Google Scholar 

  • Grundke-Iqbal I, Iqbal K, Quinlan M, Tung Y-C, Zaidi MS, Wisniewski HM (1986) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261: 6084–6089

    Google Scholar 

  • Hart MN, Merz P, Bennett-Gray J, Menezes AH, Goeken JA, Schelper RL, Wisniewski HM (1988) ß-Amyloid protein of Alzheimer’s disease is found in cerebral and spinal cord of vascular malformations. Am J Pathol 132: 167–172

    PubMed  CAS  Google Scholar 

  • Higgins GA, Lewis DA, Bahmanyar S, Goldgaber D, Gajdusek DC, Young WG, Morrison JH, Wilson MC (1988) Differential regulation of amyloid-βprotein mRNA expression within hippocampal neuronal subpopulations in Alzheimer’s disease. Proc Natl Acad Sci USA 85: 1297–1301

    Article  PubMed  CAS  Google Scholar 

  • Kang J, Lemaire H-G, Unterbeck A, Salbaum JM, Masters CL, Grzeschik K-H, Multhaup G, Beyreuther K, Müller-Hill B (1987) The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733–736

    Article  PubMed  CAS  Google Scholar 

  • Kemper TL (1983) Organization of the neuropathology of the amygdala in Alzheimer’s disease. Biological aspects of Alzheimer’s disease. Banbury Rep 15: 31–35

    Google Scholar 

  • Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H (1988) Novel precursor of Alzheimer’s disease amyloid protein shows protease inhibitory activity. Nature 331: 530–532

    Article  PubMed  CAS  Google Scholar 

  • Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC (1984) Evidence for cholinergic neurites in senile plaques. Science 226: 1443–1445

    Article  PubMed  CAS  Google Scholar 

  • Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL (1985 a) Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience 16: 691–699

    Google Scholar 

  • Kitt CA, Walker LC, Molliver ME, Price DL (1985 b) Serotonergic neurites in senile plaques of aged nonhuman primates. Anat Rec 211: 98A

    Google Scholar 

  • Koo EH, Goldgaber D, Sisodia SS, Applegate MD, Gajdusek DC, Price DL (1988) Studies of ß-amyloid precursor gene expression in brains of aged monkeys. Soc Neurosci Abstr 14: 637

    Google Scholar 

  • Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, Price DL (1990 a) Amyloid precursor protein undergoes fast anterograde axonal transport. Proc Natl Acad Sci (in press)

    Google Scholar 

  • Koo EH, Sisodia SS, Cork LC, Unterbeck A, Bayney RM, Price DL (1990 b) Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer’s disease and in aged nonhuman primates. Neuron 2: 97–104

    Google Scholar 

  • Kosik KS (1989) Minireview: the molecular and cellular pathology of Alzheimer neurofibrillary lesions. J Gerontol Biol Sci 44: B55–B58

    Article  CAS  Google Scholar 

  • Kurucz J, Charbonneau R, Kurucz A, Ramsey P (1981) Quantitative clinico-pathologic study of cerebral amyloid angiopathy. J Am Geriatr Soc 29: 61–69

    PubMed  CAS  Google Scholar 

  • Martin LJ, Cork LC, Koo EH, Sisodia SS, Weidemann A, Beyreuther K, Masters C, Price DL (1989) Localization of amyloid precursor protein ( APP) in brains of young and aged monkeys. Soc Neurosci Abstr 15: 23

    Google Scholar 

  • Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer’s disease and Down syndrome. Proc Natl Acad Sci USA 82: 4245–4249

    Article  PubMed  CAS  Google Scholar 

  • Palmeri MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG (1988) Amyloid protein precursor messenger RNAs: differential expression in Alzheimer’s disease. Science 241: 1080–1084

    Article  Google Scholar 

  • Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F, Cordell B (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331: 525–527

    Article  PubMed  CAS  Google Scholar 

  • Presty SK, Bachevalier J, Walker LC, Struble RG, Price DL, Mishkin M, Cork LC (1987) Age differences in recognition memory of the rhesus monkey ( Macaca mulatta ). Neurobiol Aging 8: 435–440

    Google Scholar 

  • Price DL, Koo EH, Unterbeck A (1989) Cellular and molecular biology of Alzheimer’s disease. BioEssays 10: 69 – 74

    Article  PubMed  CAS  Google Scholar 

  • Price DL (1986) New perspectives on Alzheimer’s disease. Annu Rev Neurosci 9: 489 – 512

    Article  PubMed  CAS  Google Scholar 

  • Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM (1987 a) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci USA 84: 4190–4194

    Google Scholar 

  • Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yau X-L, Ramakrishna N, Wolfe G, Silverman WP, Brown WT (1987 b) Chromosome 21g21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer’s disease and Down syndrome. Lancet i:384–385

    Google Scholar 

  • Schlaepfer WW, Freeman LA (1978) Neurofilament proteins of rat peripheral nerve and spinal cord. J Cell Biol 78: 653–662

    Article  PubMed  CAS  Google Scholar 

  • Selkoe DJ, Bell DS, Podlisny MB, Price DL, Cork LC (1987) Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer’s disease. Science 235: 873–877

    Article  PubMed  CAS  Google Scholar 

  • Selkoe DJ (1989) Biochemistry of altered brain proteins in Alzheimer’s disease. Annu Rev Neurosci 12: 463–490

    Article  PubMed  CAS  Google Scholar 

  • Shivers BD, Hilbich C, Multhaup G, Salbaum M, Beyreuther K, Seeburg PH (1988) Alzheimer’s disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J 7: 1365–1370

    PubMed  CAS  Google Scholar 

  • Sisodia SS, Koo EH, Martin LJ, Unterbeck AJ, Beyreuther K, Weidemann A, Price DL (1989) Biosynthesis and processing of amyloid precursor protein ( APP) in vitro. Soc Neurosci Abstr 15: 23

    Google Scholar 

  • Struble RG, Cork LC, Whitehouse PJ, Price DL (1982) Cholinergic innervation in neuritic plaques. Science 216: 413–415

    Article  PubMed  CAS  Google Scholar 

  • Struble RG, Hedreen JC, Cork LC, Price DL (1984) Acetylcholinesterase activity in senile plaques of aged macaques. Neurobiol Aging 5: 191–198

    Article  PubMed  CAS  Google Scholar 

  • Struble RG, Price DL Jr, Cork LC, Price DL (1985) Senile plaques in cortex of aged normal monkeys. Brain Res 361: 267–275

    Article  PubMed  CAS  Google Scholar 

  • Tanzi RE, Gusella JF, Watkins PC, Bruns GAP, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL (1987) Amyloid ß-protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235: 880–884

    Article  PubMed  CAS  Google Scholar 

  • Tanzi RE, McClatchey AI, Lampert ED, Villa-Komaroff L, Gusella JF, Neve RL (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer’s disease. Nature 331: 528–530

    Article  PubMed  CAS  Google Scholar 

  • van Duinen SG, Castano EM, Prelli F, Bots GTAB, Luyendijk W, Frangione B (1987) Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer’s disease. Proc Natl Acad Sci USA 84: 5991–5994

    Article  PubMed  Google Scholar 

  • Walker LC, Kitt CA, Cork LC, Struble RG, Dellovade TL, Price DL (1988 a) Multiple transmitter systems contribute neurites to individual senile plaques. J Neuropathol Exp Neurol 47: 138–144

    Google Scholar 

  • Walker LC, Kitt CA, Schwam E, Buckwald B, Garcia F, Sepinwall J, Price DL (1987) Senile plaques in aged squirrel monkeys. Neurobiol Aging 8: 291–296

    Article  PubMed  CAS  Google Scholar 

  • Walker LC, Kitt CA, Struble RG, Schmechel DE, Oertel WH, Cork LC, Price DL (1985) Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. Neurosci Lett 59: 165–169

    Article  PubMed  CAS  Google Scholar 

  • Walker LC, Kitt CA, Struble RG, Wagster MV, Price DL, Cork LC (1988 b) The neural basis of memory decline in aged monkeys. Neurobiol Aging 9: 657–666

    Google Scholar 

  • Weidemann A, König G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K (1989) Identification, biogenesis, and localization of precursors of Alzheimer’s disease A4 amyloid protein. Cell 57: 115–126

    Article  PubMed  CAS  Google Scholar 

  • Wischik CM, Novak M, Edwards PC, Klug A, Tichelaar W, Crowther RA (1988 a) Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci USA 85: 4884–4888

    Google Scholar 

  • Wischik CM, Novak M, Thogersen HC, Edwards PC, Runswick MJ, Jakes R, Walker JE, Milstein C, Roth M, Klug A (1988 b) Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci USA 85: 4506–4510

    Google Scholar 

  • Wisniewski HM, Ghetti B, Terry RD (1973) Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 32: 566–584

    Article  PubMed  CAS  Google Scholar 

  • Wong CW, Quaranta V Glenner GG (1985) Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci USA 82: 8729–8732

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman Z, Herget T, Salbaum JM, Schubert W, Hilbich C, Cramer M, Masters CL, Multhaup G, Kang J, Lemaire H-G, Beyreuther K, StarzinskiPowitz A (1988) Localization of the putative precursor of Alzheimer’s disease-specific amyloid at nuclear envelopes of adult human muscle. EMBO J 7: 367 – 373

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    D. L. Price M. D. & E. H. Koo

  2. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    E. H. Koo, S. S. Sisodia, L. J. Martin, L. C. Walker, C. A. Kitt & L. C. Cork

  3. Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    D. L. Price M. D.

  4. Division of Comparative Medicine (LCC), The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    L. C. Cork

  5. Neuropathology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    D. L. Price M. D., E. H. Koo, S. S. Sisodia, L. J. Martin, L. C. Walker, C. A. Kitt & L. C. Cork

Authors
  1. D. L. Price M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. H. Koo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. S. Sisodia
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. J. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. C. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. A. Kitt
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. C. Cork
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    Konrad Maurer , Peter Riederer  & Helmut Beckmann ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Wien

About this chapter

Cite this chapter

Price, D.L. et al. (1990). Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-3396-5_14

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82197-8

  • Online ISBN: 978-3-7091-3396-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation