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Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease

  • D. L. Price
  • E. H. Koo
  • S. S. Sisodia
  • L. J. Martin
  • L. C. Walker
  • C. A. Kitt
  • L. C. Cork
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Macaques develop age-associated cognitive/memory impairments as well as brain abnormalities (particularly senile plaques) similar to those occurring in the brains of older humans and individuals with Alzheimer’s disease (AD). Some of these abnormalities can be clarified by investigations of aged nonhuman primates. Brain tissues from animals (ranging in age from 4–35 years) were examined by RNA blotting techniques, in situ hybridization, immunoblotting, and immunocytochemistry. These approaches allowed analysis of the evolution of some of the structural/chemical alterations (formation of neurites, amyloid deposition, and neurofibrillary tangles [NFT]) that occur in these animals. These investigations have relevance for understanding some of the behavioral, neuropathological, and neurochemical abnormalities that occur in older humans and in individuals with AD.

Keywords

Senile Plaque Cerebral Amyloid Angiopathy Paired Helical Filament Aged Monkey Hereditary Cerebral Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • D. L. Price
    • 1
    • 3
    • 5
  • E. H. Koo
    • 1
    • 2
    • 5
  • S. S. Sisodia
    • 2
    • 5
  • L. J. Martin
    • 2
    • 5
  • L. C. Walker
    • 2
    • 5
  • C. A. Kitt
    • 2
    • 5
  • L. C. Cork
    • 2
    • 4
    • 5
  1. 1.Departments of NeurologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Division of Comparative Medicine (LCC)The Johns Hopkins University School of MedicineBaltimoreUSA
  5. 5.Neuropathology LaboratoryThe Johns Hopkins University School of MedicineBaltimoreUSA

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