Molecular and cellular changes associated with neurofibrillary tangles and senile plaques
Immunocytochemical studies have shown that changes in amyloid processing and in proteoglycan core proteins occur in senile plaques. Western blotting studies have shown that an extra tau species is present in Alzheimer brain and tangle-reactive neurofilament antibodies were found to be more selective towards phosphorylated neurofilaments than those that do not recognise tangles. A fragment of MAP2 was found to be present in tangles.
KeywordsDown Syndrome Neurofibrillary Tangle Senile Plaque Paired Helical Filament Western Blotting Study
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