An in vitro model for the study of the neurofibrillary degeneration of the Alzheimer type
We have recently reported that two abnormally phosphorylated Tau proteins (Tau 64 and 69) were systematically present in Alzheimer brain areas which are affected by the neurofibrillary degeneration (NFD). We suggest here that these likely early markers of the NFD might define an in vitro model for the study of the NFD. A such model might be useful to verify the different etiopathogenic hypothesis which have been proposed up to here.
KeywordsSenile Plaque Sodium Pyrophosphate Paired Helical Filament Neurofibrillary Degeneration Copper Zinc Superoxide
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- Brion JP, Passareiro H, Nunez J, Flament-Durand J (1985) Mise en évidence immunologique de la proteine tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d’Alzheimer. Arch Biol 95: 229–235Google Scholar
- Candy JM, Klinowski J, Perry RH, Perry EK, Fairbrain A, Oakley AE, Carpenter TA, Atack JR, Blessed G, Edwardson JA (1986) Aluminosilicates and senile plaque formation in Alzheimer’s disease. Lancet i: 354–356Google Scholar
- Defossez A, Beauvillain J-C, Delacourte A, Mazzuca M (1988) Alzheimer’s disease: a new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): demonstration at the electron microscope by a double immunogold labelling. Virchows Arch 413: 141–145CrossRefGoogle Scholar
- Grundke-Iqbal J, Iqbal K, Quinlan M, Tung Y-C, Zaidi MS, Wisniewski HM (1986 a) Microtubule-associated protein tau a component of alzheimer paired helical filaments. J Biol Chem 261: 6084–6089Google Scholar
- Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder LI (1986 b) Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83: 4913–4917Google Scholar
- Ihara Y, Nukina N, Miura R, Ogawara M (1986) Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer’s disease. J Biochem (Tokyo) 99: 1807–1810Google Scholar
- Ksiezak-Reding H, Binder LI, Yen S-H (1988) Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer’s disease brains with Alz 50 and Tau-1. J Biol Chem 263: 7947–7953Google Scholar
- Nukina N, Ihara Y (1986) One of the antigenic determinants of paired helical filaments is related to tau protein. J Biochem (Tokyo) 99: 1541–1544Google Scholar
- Perl DP, Brody AR (1980) Alzheimer’s disease: X-ray spectrometric evidence of aluminium accumulation in neurofibrillary tangle-bearing neurones. Science 208: 297–299Google Scholar