Neuronal plasticity of the septo-hippocampal pathway in patients suffering from dementia of Alzheimer type

  • H.-J. Gertz
  • J. Cervos-Navarro
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Quantitative morphological examination of nerve cell number of the medial septal nuclei (area CHl) and of the vertical limb of the diagonal band of Broca (area CH2) and of spine density of fascia dentata dendrites was performed in DAT and control cases. The data revealed that compensatory axonal sprouting of surviving axons seems to replace lost cholinergic afference of fascia dentata cells after degeneration of the basal forebrain nuclei. Changes of fascia dentata innervation may be an additional pathogenetic factor in dementia of Alzheimer’s type.


Spine Density Neuronal Plasticity Senile Dementia Apical Dendrite Perforant Path 
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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • H.-J. Gertz
    • 1
  • J. Cervos-Navarro
    • 1
  1. 1.Departments of Gerontopsychiatry, and NeuropathologyFree University BerlinBerlin 19Germany

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