Neuronal plasticity of the septo-hippocampal pathway in patients suffering from dementia of Alzheimer type
Quantitative morphological examination of nerve cell number of the medial septal nuclei (area CHl) and of the vertical limb of the diagonal band of Broca (area CH2) and of spine density of fascia dentata dendrites was performed in DAT and control cases. The data revealed that compensatory axonal sprouting of surviving axons seems to replace lost cholinergic afference of fascia dentata cells after degeneration of the basal forebrain nuclei. Changes of fascia dentata innervation may be an additional pathogenetic factor in dementia of Alzheimer’s type.
KeywordsSpine Density Neuronal Plasticity Senile Dementia Apical Dendrite Perforant Path
Unable to display preview. Download preview PDF.
- Cotman CW, Lewis ER, Hand D (1981) The critical afferent theory: a mechanism to account for septohippocampal development and plasticity. In: Flohr H, Precht W (eds) Lesion-induced neuronal plasticity in sensorimotor systems. Springer, Berlin Heidelberg New York, pp 13–26Google Scholar
- DeRuiter JP, Uylings HBM (1987) Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia. Brain Res 402: 217–229Google Scholar
- Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation. Science 225: 1168 —1170Google Scholar
- Paranavelas IG, Lynch G, Brecha N, Cotman CW, Globus A (1974) Spine loss and regrowth in hippocampus following deafferentiation. Nature (London) 248: 71– 73Google Scholar