Summary
Quantitative morphological examination of nerve cell number of the medial septal nuclei (area CHl) and of the vertical limb of the diagonal band of Broca (area CH2) and of spine density of fascia dentata dendrites was performed in DAT and control cases. The data revealed that compensatory axonal sprouting of surviving axons seems to replace lost cholinergic afference of fascia dentata cells after degeneration of the basal forebrain nuclei. Changes of fascia dentata innervation may be an additional pathogenetic factor in dementia of Alzheimer’s type.
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© 1990 Springer-Verlag Wien
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Gertz, HJ., Cervos-Navarro, J. (1990). Neuronal plasticity of the septo-hippocampal pathway in patients suffering from dementia of Alzheimer type. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_10
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_10
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82197-8
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