Neuropeptide levels in Alzheimer’s disease and dementia with frontotemporal degeneration

  • L. Minthon
  • L. Edvinsson
  • R. Ekman
  • L. Gustafson
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 30)


The CSF levels of somatostatin-LI (SLI), neuropeptide Y (NPY-LI) and Delta Sleep Inducing Peptide (DSIP-LI) have been measured in patients with dementia of Alzheimer type (DAT) and dementia with frontotemporal degeneration of non-Alzheimer type (FTD). The distribution pattern of cortical degeneration differs between these two types of dementia. DAT shows degeneration of mainly temporo-parietal and temporo-limbic structures, whereas FTD discloses its main degeneration in the frontotemporal regions (Brun, 1987). The somatostatin-LI was significantly reduced both in DAT and FTD. NPY-LI showed a significant reduction in DAT but not in FTD. A tendency to a reduction with duration of the disease was observed in DAT whereas the contrary was noted in FTD. The DSIP-LI levels were reduced in DAT and slightly increased in FTD. The study provides an evidence of neurochemical differences between the two primary degenerative dementias.


High Performance Liquid Chroma High Performance Liquid Chroma Delta Sleep Induce Peptide Diagnostic Score Ischemic Score 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. Minthon
    • 1
    • 4
  • L. Edvinsson
    • 2
  • R. Ekman
    • 3
  • L. Gustafson
    • 1
  1. 1.Departments of PsychogeriatricsUniversity of LundLundSweden
  2. 2.Internal MedicineUniversity of LundLundSweden
  3. 3.Psychiatry and NeurochemistryUniversity of LundLundSweden
  4. 4.Department of PsychogeriatricsUniversity of LundLundSweden

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