Changes of acetylcholine and choline concentrations in cerebrospinal fluids of normal subjects and patients with dementia of Alzheimer-type
Acetylcholine (ACh) and choline (Ch) in cerebrospinal fluid from 29 normal volunteers and 7 patients with Alzheimer-type dementia (DAT) were examined using high-performance liquid chromatography with electrochemical detector coupled with liquid cation-exchange method. In normal volunteers, ACh concentration was decreased significantly from 40–50 years and Ch concentration was increased significantly from 50–60 years. CSF from patients with DAT revealed high Ch concentration and the increase was statistically significant while ACh concentration in CSF of DAT did not show a significant difference with that of normal volunteers. This Ch augmentation may suggest a disturbance in utilization of Ch for ACh synthesis and may become an useful indicator for organic changes in central cholinergic system.
KeywordsBrospinal Fluid Choline Concentration Tetramethylammonium Chloride Choline Acetyl Central Cholinergic System
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- Ikeda Y, Ohshiro K, Tomoda K, Fujiki Y, Okuyama S, Itoh T, Yamauchi T (1989) Ageing-induced memory deficit indicated by newly-developed memory test. Abstr Fourth Congress of the International Psychogeriatric Association, p 120Google Scholar
- McGeer EG, McGeer PL (1976) Neurotransmitter metabolism in the aging brain. In: Terry RD, et al (eds) Neurobiology of aging. Raven Press, New York, p 389Google Scholar