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Changes of acetylcholine and choline concentrations in cerebrospinal fluids of normal subjects and patients with dementia of Alzheimer-type

  • Y. Ikeda
  • S. Okuyama
  • Y. Fujiki
  • K. Tomoda
  • K. Ohshiro
  • T. Itoh
  • T. Yamauchi
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 30)

Summary

Acetylcholine (ACh) and choline (Ch) in cerebrospinal fluid from 29 normal volunteers and 7 patients with Alzheimer-type dementia (DAT) were examined using high-performance liquid chromatography with electrochemical detector coupled with liquid cation-exchange method. In normal volunteers, ACh concentration was decreased significantly from 40–50 years and Ch concentration was increased significantly from 50–60 years. CSF from patients with DAT revealed high Ch concentration and the increase was statistically significant while ACh concentration in CSF of DAT did not show a significant difference with that of normal volunteers. This Ch augmentation may suggest a disturbance in utilization of Ch for ACh synthesis and may become an useful indicator for organic changes in central cholinergic system.

Keywords

Brospinal Fluid Choline Concentration Tetramethylammonium Chloride Choline Acetyl Central Cholinergic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Y. Ikeda
    • 1
    • 2
  • S. Okuyama
    • 1
  • Y. Fujiki
    • 1
  • K. Tomoda
    • 1
  • K. Ohshiro
    • 1
  • T. Itoh
    • 1
  • T. Yamauchi
    • 1
  1. 1.Department of Psychiatry, School of MedicineFujita Health UniversityAichiJapan
  2. 2.Department of Psychiatry, School of MedicineFujita Health UniversityAichiJapan

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