Some effects of CNS cholinergic neurons on memory

  • T. Goto
  • F. Kuzuya
  • H. Endo
  • T. Tajima
  • H. Ikari
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 30)


The aim of this study is to observe the relationship between the impairment in passive avoidance task induced in rats by the i. p. administration of muscarinic antagonists, scopolamine and methyl-scopolamine, and the change in acetylcholine (ACh) output induced by these drugs. Initially we studied the effects of these drugs on the animals’ performance of a step-through passive avoidance task. We then measured the change in ACh levels after administration of these drugs using an in vivo brain dialysis technique. Scopolamine was effective in impairing the performance of the passive avoidance task, while methyl-scopolamine did not have clear effects on the performance of the task. With regard to ACh output, scopolamine increased ACh dose-dependently and methyl-scopolamine also affected ACh release. These data suggest that the accumulation of ACh in the synaptic cleft may be involved in the memory deficit induced by scopolamine.


Passive Avoidance Cholinergic Neuron Guide Cannula Dark Compartment Passive Avoidance Task 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • T. Goto
    • 1
    • 2
  • F. Kuzuya
    • 2
  • H. Endo
    • 2
  • T. Tajima
    • 2
  • H. Ikari
    • 2
  1. 1.Department of GeriatricsNagoya University School of MedicineShowa-Ku, Nagoya, 466Japan
  2. 2.Department of GeriatricsNagoya University School of MedicineNagoyaJapan

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