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Developmental Neuropathology pp 505–518Cite as

Involvement of the CNS in Certain Hematologic Diseases of Infancy and Childhood

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Abstract

A bleeding disposition in the newborn infant may result from: 1. thrombocytopenia, 2. vitamin K deficiency, 3. a temporary insufficiency in hepatic synthesis of coagulation factors because of immaturity or due to hepatic damage by anoxia or infectious diseases, and 4. inherited anomalies of the coagulation mechanism. Intracranial or cerebral hemorrhages may be caused by any of these disease processes. Their neuropathologic documentation for infants is scanty, but the available observations suggest that the type of bleeding does not vary significantly with the various etiologies. The most common form of intracranial bleeding in hemorrhagic diseases of the newborn appears to be subarachnoid hemorrhage, and the subsequent development of obstructive hydrocephalus has been described in several reports.

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References

  • Bartman, J., Van de Velde, R. L., Friedmann, F.: Pigmented lipid histiocytes and susceptibility to infection: ultrastructure of splenic histiocytes. Pediatrics 40: 1000–1002, 1967.

    PubMed  CAS  Google Scholar 

  • Beguez-Cesar, A.: Neutropenia cronica maligna familiar con granulaciones atipicas de los leucocitos. Bol. Soc. Cub. Pediat. 15: 900–922, 1943.

    Google Scholar 

  • Bell, R. J. M., Bradfield, A. J. E., Barnes, N. D., France, N. E.: Familial haemophagocytic reticulosis. Arch. Dis. Child. 43: 601–606, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Berendes, H., Bridges, R. A., Good, R. A.: A fatal granulomatosis of childhood. Minn. Med. 40: 309–312, 1957.

    PubMed  CAS  Google Scholar 

  • Carson, M. J., Chadwick, D. L., Brubaker, C. A., Cleland, R. S., Landing, B. H.: Thirteen boys with progressive septic granulomas. Pediatrics 35: 405–412, 1965.

    PubMed  CAS  Google Scholar 

  • Chediak, M.: Nouvelle anomalie leucocytaire de charactère constitutionel et familial. Nouv. Rev. franc. Hémat. 7: 362–367, 1952.

    CAS  Google Scholar 

  • Cooper, H. A., Bowie, E. J. W., Bugert, E. O., Jr., Mellinger, J. F.: Hydrocephalus in child with von Willebrand’s disease. Amer. J. Dis. Child. 121: 340–343, 1971.

    PubMed  CAS  Google Scholar 

  • Dayan, A. D.: Chronic encephalitis in children with severe immuno-deficiency. Acta neuropath. (Berl.) 19: 234–241, 1971.

    Article  CAS  Google Scholar 

  • Donohue, W. L., Bain, H. W.: Chediak-Higashi syndrome. Pediatrics 20: 416–430, 1957.

    PubMed  CAS  Google Scholar 

  • Farquhar, J. W., Claireaux, A. E.: Familial haemophagocytic reticulosis. Arch. Dis. Child. 27: 519–525, 1952.

    Article  PubMed  CAS  Google Scholar 

  • Freireich, E. J., Thomas, L. B., Frei, E., Fritz, R. D., Forkner, C. E.: A distinctive type of intracerebral hemorrhages associated with “blastic crisis” in patients with leukemia. Cancer 13: 146–154, 1960.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, R. R., Dean, T.: Foetal deaths from antenatal anticoagulant therapy. Brit. med. J. 2: 719–721, 1955.

    Article  PubMed  CAS  Google Scholar 

  • Hanissian, A. S., Jabbour, J. T., De Lamerens, S., Garcia, J. H., Horta-Barbosa, L.: Subacute encephalitis and hypogammaglobulinemia. Amer. J. Dis. Child. 123: 151–155, 1972.

    PubMed  CAS  Google Scholar 

  • Hartmann, J. R., Diamond, L. K.: Haemophilia and related haemorrhagic disorders. Practitioner 178: 179–190, 1957.

    PubMed  Google Scholar 

  • Haupt, H.: Störungen der Blutgerinnung infolge perinataler Hirnschädigung. Dtsch. med. Wschr. 90: 1473–1477, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Higashi, O.: Congenital gigantism of proxidase granules. Tohoku J. exp. Med. 59: 315–332, 1954.

    Article  PubMed  CAS  Google Scholar 

  • Holmes, B., Quie, P. G., Windhorst, D. B., Good, R. A.: Fatal granulomatous disease of childhood. Lancet 1: 1225–1228, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Høyerall, H. M., Lamvik, J., Moe, P. J.: Congenital hypoplastic thrombocytopenia and cerebral malformations in two brothers. Acta paed. scand. 59: 185–191, 1970.

    Article  Google Scholar 

  • Iversen, T.: Leukaemia in infancy and childhood. Acta paediat. scand. Suppl. 106: 1–219, 1966.

    Google Scholar 

  • Keely, M. L., Taylor, N., Chard, R. L. Fr.: Spinal cord compression as a complication of haemophilia. Arch. Dis. Child. 47: 826–827, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Landing, B. H., Shirkey, H. S.: A syndrome of recurrent infection and infiltration of viscera by pigmented lipid histiocytes. Pediatrics 20: 431–438, 1957.

    PubMed  CAS  Google Scholar 

  • Leader, R. W., Padgett, G. A., Gorham, J. R.: Studies of abnormal leukocyte bodies in the mink. Blood 22: 477–484, 1963.

    PubMed  CAS  Google Scholar 

  • Lockman, L. A., Kennedy, W. R., White, J. G.: The Chediak-Higashi syndrome: Electrophysiologic and electron microscopic observations on the peripheral neuropathy. J. Pediat. 70: 942–951, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Lutzner, M. A., Lowrie, C. T., Jordan, H. W.: Giant granules in leukocytes of the beige mouse. J. Hered. 58: 299–300, 1967.

    PubMed  CAS  Google Scholar 

  • MacMahon, H. E., Bedizel, M., Ellis, C. A.: Familial erythrophagocytic lymphohistiocytosis. Pediatrics 32: 868–879, 1963.

    PubMed  CAS  Google Scholar 

  • McCarthy, J. W., Coble, L. L.: Intracranial hemorrhage and subsequent communicating hydrocephalus in a neonate with classical hemophilia. Pediatrics 51: 123–124, 1973.

    Google Scholar 

  • Moore, E. W., Thomas, L. B., Shaw, R. K., Freireich, E. J.: The central nervous system in acute leucemia. Arch. intern. Med. 105: 451–468, 1960.

    Article  PubMed  CAS  Google Scholar 

  • Padgett, G. A., Leader, R. W., Gorham, J. R., O’Mary, C. C.: The familial occurrence of the Chediak-Higashi syndrome in mink and cattle. Genetics 49: 505–512, 1964.

    PubMed  CAS  Google Scholar 

  • Pearson, H. A., Shulman, N. R., Marder, V. J., Cone, T. E.: Isoimmune neonatal thrombocytopenic purpura. Blood 23: 154–177, 1964.

    PubMed  CAS  Google Scholar 

  • Porter, F., Thurman, W. G.: Studies of sickle cell disease. Amer. J. Dis. Child. 106: 35–42, 1963.

    Google Scholar 

  • Price, D. L., Woolsey, J. E., Rosman, N. P., Richardson, E. P.: Familial lymphohistiocytosis of the nervous system. Arch. Neurol. (Chic.) 24: 270–283, 1971.

    Article  CAS  Google Scholar 

  • Price, R. A., Johnson, W. W.: The central nervous system in childhood leukemia. I. The arachnoid. Cancer 31: 520–533, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Prieur, D. J., Davis, W. C., Padgett, G. A.: Defective function of renal lysosomes in mice with Chediak-Higashi syndrome. Amer. J. Path. 67: 227–240, 1972.

    PubMed  CAS  Google Scholar 

  • Reese, A. J. M., Levy, E.: Familial incidence of non-lipoid reticulo-endotheliosis (LettererSiwe disease). Arch. Dis. Child. 26: 578–581, 1951.

    Article  PubMed  CAS  Google Scholar 

  • Schenk, W. D.: Hemorrhage in spinal cord with syringomyelia in a patient with hemophilia. Acta neuropath. (Berl.) 2: 306–308, 1963.

    Article  Google Scholar 

  • Silverstein, A.: Intracranial bleeding in hemophilia. Arch. Neurol. 3: 141–157, 1960.

    Article  PubMed  CAS  Google Scholar 

  • Steinbrinck, W.: Über eine neue Granulationsanomalie der Leukozyten. Dtsch. Arch. klin. Med. 193: 577–581, 1948.

    Google Scholar 

  • Sung, J. H., Meyers, J. P., Stadlan, E. M., Cowen, D., Wolf, A.: Neuropathological changes in Chediak-Higashi disease. J. Neuropath. exp. Neurol. 28: 86–118, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Veiga, S., Vaithianathan, T.: Massive intravascular sickling after exchange transfusion with sickle cell trait blood. Transfusion 3: 387–391, 1963.

    Article  PubMed  CAS  Google Scholar 

  • Verhaart, W. J. C.: Polio-encephalopathy or masked encephalitis in familial hypogammaglobulinemia. J. Neuropath. exp. Neurol. 20: 380–385, 1961.

    Article  PubMed  CAS  Google Scholar 

  • Von Sydow, G.: Hypopotrombinemi och hjarnskada hos barn till dikumarinbehandlad moder. Nordisk. Medicin 34: 1171–1172, 1947.

    PubMed  CAS  Google Scholar 

  • White, H. H., Kepes, J. H., Kirkpatrick, C. H., Schimke, R. N.: Subacute encephalitis and congenital hypogammaglobulinemia. Arch. Neurol. (Chic.) 26: 359–365, 1972.

    Article  CAS  Google Scholar 

  • White, J. G.: The Chediak-Higashi syndrome: a possible lysosomal disease. Blood 28: 143–156, 1966.

    PubMed  CAS  Google Scholar 

  • Willi, H.: Die Blutungskrankheiten des Neugeborenen. Erg. inn. Med. Kinderheilk. 2: 467–543, 1951.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Reinhard L. Friede M.D. (Professor of Neuropathology)

  2. University of Zurich, Switzerland

    Reinhard L. Friede M.D. (Professor of Neuropathology)

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  1. Reinhard L. Friede M.D.
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© 1975 Springer-Verlag Wien

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Friede, R.L. (1975). Involvement of the CNS in Certain Hematologic Diseases of Infancy and Childhood. In: Developmental Neuropathology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3338-5_46

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  • DOI: https://doi.org/10.1007/978-3-7091-3338-5_46

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3340-8

  • Online ISBN: 978-3-7091-3338-5

  • eBook Packages: Springer Book Archive

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