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Axon Dystrophies

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Developmental Neuropathology

Abstract

One may assume that infantile neuraxonal dystrophy (Seitelberger disease)—once its chemical background becomes better understood—will be classified among the inherited metabolic defects. There are, however, other forms of axon dystrophy which clearly do not qualify as inherited metabolic diseases, like those associated with normal or premature aging or with toxic or nutritional derangements. Furthermore, a nonspecific swelling of axon’ upon local injury is a very common tissue response seen with a great variety of lesions. All these types of swollen axons are morphologically similar, particularly on light microscopic examination. It was considered advantageous, therefore, to review neuraxonal dystrophy within a general frame of classification of axon swellings.

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References

  • Bischoff, A., Regli, F.: Die Hallervorden-Spatzsche Krankheit. Arch. Psychiat. Nervenkr. 204: 589–602, 1963.

    Article  CAS  Google Scholar 

  • Berard-Badier, M., Gamberelli, D., Pinsard, N., et al.: Infantile neuroaxonal dystrophy or Seitelberger’s disease. II. Peripheral nerve involvement: Electron microscopic study in one case. Acta neuropath. (Berl.) Suppl. V: 30–39, 1971.

    Google Scholar 

  • Blakemore, W. F., Cavanagh, J. B.: “Neuroaxonal dystrophy” occurring in an experimental “dying back” process in the rat. Brain 92: 789–804, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Cordy, D. R., Richards, W. P., Bradford, G. E.: Systemic neuraxonal dystrophy in Suffolk sheep. Acta neuropath. (Berl.) 8: 113–140, 1967.

    Article  Google Scholar 

  • Cowen, D., Olmstead, E. V.: Infantile neuroaxonal dystrophy. J. Neuropath. exp. Neurol. 22: 175–236, 1963.

    Article  PubMed  CAS  Google Scholar 

  • Defendini, R., Markesbery, W. R., Mastri, A. R., Duffy, P. E.: Hallervorden-Spatz disease and infantile neuroaxonal dystrophy. Ultrastructural observations, anatomical pathology and nosology. J. Neurol. Sci. 20: 7–23, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Dooling, E. C., Schoene, W. C., Richardson, E. P.: Hallervorden-Spatz syndrome. Arch. Neurol. (Chic.) 30: 70–83, 1974.

    Article  CAS  Google Scholar 

  • Eicke, W. J.: Neue Beobachtungen über die Hallervorden-Spatzsche Krankheit. Arch. Psychiat. Nervenkr. 11: 514–546, 1940.

    Article  Google Scholar 

  • Fitch, N., Carpenter, S., Lahance, R. C.: Prenatal axonal dystrophy and osteoporosis. Arch. Path. (Chic.) 95: 297–301, 1973.

    Google Scholar 

  • Friede, R. L., Knoller, M.: Proximo-diatal increase in enzymic activity in the dorsal spinal tracts. J. Neurochem. 11: 679–686, 1964.

    Article  PubMed  CAS  Google Scholar 

  • Fujisawa, K.: A unique type of axon alteration, so-called axonal dystrophy as seen in Gol1’s nucleus of 277 cases of controls. Acta neuropath. (Berl.) 8: 255–275, 1967.

    Article  CAS  Google Scholar 

  • Gilman, S., Barrett, R. E.: Hallervorden-Spatz disease and infantile neuroaxonal dystrophy. Clinical characteristics and nosological considerations. J. Neurol. Sci. 19: 189–205, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Haberland, C., Brunngraber, E. G., Witting, L. A.: Infantile neuroaxonal dystrophy. Neuropathological and biochemical study of a case. Arch. Neurol. (Chic.) 26: 391–402, 1972.

    Article  CAS  Google Scholar 

  • Hedley-Whyte, E. T., Gilles, F. H., Uzman, B. G.: Infantile neuroaxonal dystrophy. A disease characterized by altered terminal axons and synaptic endings. Neurol. (Minneap.) 18: 892–906, 1968.

    Google Scholar 

  • Herman, M. M., Huttenlocher, P. R., Bensch, K. G.: Electron microscopic observations in infantile neuroaxonal dystrophy. Report of a cortical biopsy and review of the recent literature. Arch. Neurol. (Chic.) 20: 19–34, 1969.

    Article  CAS  Google Scholar 

  • Huttenlccher, P. R., Gilles, F. H.: Infantile neuroaxonal dystrophy: Clinical, pathologic and histochemical findings in a family with 3 affected siblings. Neurology (Minneap.) 17: 1174–1184, 1967.

    Article  Google Scholar 

  • Indravasu, S., Dexter, R. A.: Infantile neuroaxonal dystrophy and its relationship to Hallervorden-Spatz disease. Neurology (Minneap.) 18: 693–699, 1968.

    Article  CAS  Google Scholar 

  • Jellinger, K., Jirásek, A.: Neuroaxonal dystrophy in man: Character and natural history. Acta neuropath. (Berl.) Suppl. V: 3–16, 1971.

    Google Scholar 

  • Jellinger, K., Seitelberger, F.: Infantile neuroaxonale Dystrophie. Frühformn mit bevorzugtem Kleinhirnbefall. Acta neuropath. (Berl.) 10: 123–131, 1968.

    Article  CAS  Google Scholar 

  • Kamoshita, S., Neustein, H. B., Landing, B. H.: Infantile neuroaxonal dystrophy with neonatal onset. Neuropathologic and electron microscopic observations. J. Neuropath. exp. Neurol. 27: 300–323, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Lampen, P., Blumberg, J. M., Pentschew, A.: An electron microscopic study of dystrophic axons in the gracile and cuneate nuclei of vitamin E-deficient rats. J. Neuropath. exp. Neurol. 28: 60–77, 1964.

    Google Scholar 

  • Lampert, P. W.: A comparative electron microscopic study of reactive, degenerating, regenerating, and dystrophic axons. J. Neuropath. exp. Neurol. 26: 345–368, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Lindenberg, R., Freytag, E.: Brainstem lesions characteristic of traumatic hyperextension of the head. Arch. Path. (Chic.) 90: 509–515, 1970.

    CAS  Google Scholar 

  • Newberne, J. W., Robinson, V. B., Estill, L., Brinkman, D. C.: Granular structures in brains of apparently normal digs. Amer. J. vet. Res. 21: 782–786, 1960.

    PubMed  CAS  Google Scholar 

  • Pentschew, A., Schwarz, K.: Systemic axonal dystrophy in vitamin E deficient adult rats. With implication in human neuropathology. Acta neuropath. (Berl.) 1: 313–334, 1962.

    Article  Google Scholar 

  • Rabinowicz, T., Wildi, E.: Spastic amaurotic axonal idiocy. A familial juvenile form of a lipo-glyco-protidic thesaurismosis including a pallidal siderosis. In: Cerebral Lipoidoses (Cumings, J. N., ed.), pp. 34–47. Springfield, Ill.: Thomas 1957.

    Google Scholar 

  • Richter, E.: Ein Beitrag zur infantilen neuro-axonalen Dystrophie. Vergleich der histopathologischen Befunde und des klinischen Bildes mit der Hallervorden-Spatzschen Krankheit. Z. Neurol. 201: 160–195, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Sandbank, U., Lerman, P., Geifman, M.: Infantile neuroaxonal dystrophy: Cortical anoxic and presynaptic changes. Acta neuropath. (Berl.) 16: 342–352, 1970.

    Article  CAS  Google Scholar 

  • Seitelberger, F.: Eine unbekannte Form von infantiler lipoidspeichernder Krankheit des Gehirns. Proc. First Int. Congr. Neuropath., Rome 3: 323–333, 1952, Rosenberg and Sellier, Torino.

    Google Scholar 

  • Sengel, A., Stoebner, P.: Intérê de la biopsie neuro-musculaire dans le diagnostic de la dystrophie neuro-axonale infantile. Etude ultrastructurale de 3 cas dont 2 familiaux. Acta neuropath. (Berl.) 21: 109–216, 1972.

    Article  CAS  Google Scholar 

  • Slagel, D. E., Hartmann, H. A.: The distribution of neuroaxonal lesions in mice injected with iminodipropionitrile with special reference to the vestibular system. J. Neuropath. exp. Neurol. 24: 599–620, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Sung, J. H.: Neuroaxonal dystrophy in mucoviscidosis. J. Neuropath. exp. Neurol. 23: 567–583, 1964.

    Article  PubMed  CAS  Google Scholar 

  • Jellinger, K., Stadlan, E. M.: Neuraxonal dystrophy in congenital biliary atresia. J. Neuropath. exp. Neurol. 25: 118–120, 1966.

    Google Scholar 

  • Thilbault, J.: Neuroaxonal dystrophy. A case of nonpigmented type and protracted course. Acta neuropath. (Berl.) 21: 232–238, 1972.

    Article  Google Scholar 

  • Toga, M., Berard-Badier, M., Bambarelli-Dubois, D.: La dystrophie neuroaxonale infantile ou maladie de Seitelberger. Etude clinique, histologique et ultrastructurale de deux observations. Acta neuropath. (Berl.) 15: 327–350, 1970.

    Article  CAS  Google Scholar 

  • Vandermeer, J., Barto, E.: Axonal dystrophy in a deer mouse (peromyscus maniculatus) with an inherited ataxia and tremor. J. Neuropath. exp. Neurol. 28: 257–266, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Woodward, J. C., Collins, G. H., Hessler, J. R.: Feline hereditary neuraxonal dystrophy. Amer. J. Path. 74: 551–566, 1974.

    Google Scholar 

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Authors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Reinhard L. Friede M.D. (Professor of Neuropathology)

  2. University of Zurich, Switzerland

    Reinhard L. Friede M.D. (Professor of Neuropathology)

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  1. Reinhard L. Friede M.D.
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© 1975 Springer-Verlag Wien

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Friede, R.L. (1975). Axon Dystrophies. In: Developmental Neuropathology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3338-5_43

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  • DOI: https://doi.org/10.1007/978-3-7091-3338-5_43

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3340-8

  • Online ISBN: 978-3-7091-3338-5

  • eBook Packages: Springer Book Archive

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