Adreno-Leukodystrophy and Its Relation to “Schilder Disease”

  • Reinhard L. Friede


Clinicopathologic documentation of the concurrence of a sudanophilic leukodystrophy indistinguishable from “Schilder disease” with adrenal insufficiency was first reported by Siemerling and Creutzfeldt (1923). A review by Hoefnagel et al. (1962) found only 4 other cases, but the number increased rapidly in the subsequent literature (See et al., 1971, references). The publication of a series of 9 cases by Powers and Schaumburg (1973) has focussed considerable interest on the disease, and it reopened the problem of its nosologic distinction from “Schilder disease”, as discussed at the end of this chapter. A recent review of the literature (Powell et al., 1975) accounts for about 50 cases.


White Matter Adrenal Insufficiency Neurologic Disorder Zona Fasciculata Centrum Semiovale 
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Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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