Dysplasias of Cerebral Hemispheric Organization

  • Reinhard L. Friede


The facial deformities associated with holoprosencephaly are—as those of anencephaly— obvious and unmistakable, and early descriptions go back to the medieval literature (Frutiger, 1969). The first reports on the morbid anatomy were published during the nineteenth century, but the classification and identification of the characteristic morphologic features of these lesions is based on the comprehensive treatise of Kundrat (1882). A considerable number of reports on cyclopia and arhinencephaly in man and domesticated animals were published during the first half of this century and were reviewed by Köhn (1952). More recently, series of cases were studied by Yakovlev (1959), De Myer et al. (1964), Robain and Gorce (1972), and Jellinger and Gross (1973).


Corpus Callosum Olfactory Bulb Septum Pellucidum Cavum Septi Pellucidi Facial Deformity 
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Copyright information

© Springer-Verlag Wien 1975

Authors and Affiliations

  • Reinhard L. Friede
    • 1
    • 2
  1. 1.Case Western Reserve UniversityClevelandUSA
  2. 2.University of ZurichSwitzerland

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