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Naftidrofuryl

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Neuro-Psychopharmaka

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Zusammenfassung

Eine Hauptwirkung von Naftidrofuryl liegt in seinem Serotonin-Antagonismus gegen(Aber 5-HT2-Rezeptoren von Arterien und Arteriolen (Matoteaux et al. 1986, Verheggen und Schrör 1988, Bodin et al. 1989, Hollenberg 1988). Hypoxische Bedingun gen führen in den Hirngefäßen zu einer Zunahme der vasokonstriktorischen Wirkung von Serotonin, die über 5-HT2-Rezeptoren vermittelt wird (Katusic und Vanhoutte 1986, Vanhoutte und Luscher 1986); gleichzeitig wird der Abbau dieses Transmitters verlangsamt (Gluts 1985). Höheres Alter und arteriosklerotische Veränderungen verstärken darüber hinaus die vasokonstriktorische Reagibilität auf 5-HT (De Mey und Vanhoutte 1981, Cohen et al. 1987, Vanhouite 1988, Heistad et al. 1987, Hollenberg 1988, Vanhoutte 1987).

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Authors
  1. H. Herrschaft
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Editors and Affiliations

  1. Psychiatrische Universitätsklinik, Würzburg, Bundesrepublik Deutschland

    Peter Riederer

  2. Psychiatrische Universitätsklinik, Bonn, Bundesrepublik Deutschland

    Gerd Laux

  3. Psychiatrische Universitätsklinik, Basel, Schweiz

    Walter Pöldinger

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© 1992 Springer-Verlag Wien

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Herrschaft, H. (1992). Naftidrofuryl. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3330-9_19

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  • DOI: https://doi.org/10.1007/978-3-7091-3330-9_19

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