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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 29 pp 140–208Cite as

The Chemistry of Glutarimide Antibiotics

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Abstract

The glutarimide antibiotics constitute a group of near-neutral naturally-occurring substances whose discovery was heralded in 1946 by the isolation of a substance, called actidione (later changed to cy cloheximide: vide infra) from a streptomycin-producing strain of Streptomvices griselts (129). Although this material displayed little or no activity against the usual pathogenic bacteria, it was found to be very effective in inhibiting the growth of many fungi. The characteristic feature of these antibiotics is the 3-ethylglutarimide group which is substituted at only the β-position of the ethyl group.

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  1. Wayland, Massachusetts, USA

    F. Johnson

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  1. F. Johnson
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  1. Tallahassee, Fla., USA

    W. Herƶ

  2. Freiburg i. Br., Germany

    H. Grisebach

  3. Loughborough, Leics., UK

    G. W. Kirby

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Johnson, F. (1971). The Chemistry of Glutarimide Antibiotics. In: Herƶ, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 29. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 29. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3259-3_3

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