Remodeling of Arteries in Response to Changes in their Mechanical Environment

  • Alexander Rachev
Part of the International Centre for Mechanical Sciences book series (CISM, volume 441)


Arteries are subjected to mechanical forces, which may vary in time. A long-lasting alteration in pressure and/or blood flow rate causes an adaptive response termed remodeling. At the macro-level remodeling is manifest as a change in arterial geometry and a change in mechanical properties of the arterial tissue. A review of the main experimental findings concerning pressure- and flow-induced remodeling of large arteries is presented. Theoretical models of volumetric and global growth based on a continuum mechanics approach are discussed. Some specific biomechanical problems of arterial remodeling associated with abnormal narrowing of the arterial lumen are considered.


Wall Shear Stress Arterial Wall Circumferential Stress Mechanical Environment Stretch Ratio 


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© Springer-Verlag Wien 2003

Authors and Affiliations

  • Alexander Rachev
    • 1
  1. 1.Institute of MechanicsBulgarian Academy of SciencesSofiaBulgaria

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