From Left Ventricular Dynamics to the Pathophysiology of the Failing Heart

  • Antonio Barsotti
  • Frank Lloyd Dini
Part of the International Centre for Mechanical Sciences book series (CISM, volume 446)


The mechanical function of the heart can be described by the pressure, volume and flow changes. The contracting left ventricle can be viewed as an impulse generator that rapidly accelerates blood to a high peak outflow velocity early in its ejection period. The driving force for the flow of blood is the total energy imparted to it that corresponds to the mechanical, external work performed by the ventricle. The shape and structure of the ventricle play a major role in the transfer of mechanical energy from myocytes, to myocardial wall, to the ventricular cavity, where it is used for cardiac pump function.


Left Ventricle Stroke Volume Wall Stress Myocardial Oxygen Consumption External Work 


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Copyright information

© Springer-Verlag Wien 2003

Authors and Affiliations

  • Antonio Barsotti
    • 1
  • Frank Lloyd Dini
    • 2
  1. 1.Dipartimento di Medicina Interna e Specialità MedicheCattedra di Cardiologia. Università degliFrance
  2. 2.Azienda Ospedaliera PisanaUnità di Malattie Cardiovascolari IIPisaItaly

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