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Tryptophan Accumulation by Blood Platelets of Depressed Patients

  • K. Wood
  • C. Swade
  • A. Coppen
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 15)

Summary

The accumulation of tryptophan by blood platelets has been investigated in depressive patients and controls using short incubation times and low substrate concentrations. The accumulation of tryptophan by the platelet is significantly greater in the acutely depressed patients than the control group. The results are discussed with reference to tryptophan transport in depression and also to the regulation of plasma levels of tryptophan.

Keywords

Depressed Patient Blood Platelet Depressive Illness Short Incubation Time Neural Transmission 
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References

  1. Boullin, D. J., Green, A. R.: Mechanisms by which human blood platelets accumulate glycine, GABA and amino acid precursors of putative neurotransmitters. Br. J. Pharmac. 45, 83–94 (1972).CrossRefGoogle Scholar
  2. Coppen, A., Brooksbank, B. W. L., Eccleston, E., Peet, M., White, S. G.: Tryptophan metabolism in depressive illness. Psychol. Med. 4, 164–173 (1974).PubMedCrossRefGoogle Scholar
  3. Coppen, A., Swade, C, Wood, K.: Platelet 5-hydroxytryptamine accumulation in depressive illness. Clin. Chim. Acta 87, 165–168 (1978).PubMedCrossRefGoogle Scholar
  4. Hallstrom, C. O. S., Rees, W. L., Pare, C. M. B., Trenchard, A., Turner, P.: Platelet uptake of 5-hydroxytryptamine and dopamine in depression. Postgrad. Med. J. 52, 40–44 (1976).PubMedCrossRefGoogle Scholar
  5. Hamilton, M.: A rating scale for depression. J. Neurol. Neurosurg. Psychiat. 23, 56–62 (1960).PubMedCrossRefGoogle Scholar
  6. Lineweaver, H., Burk, D.: The determination of enzyme dissociation constants. J. Am. Chem. Soc. 56, 658–666 (1934).CrossRefGoogle Scholar
  7. Shaw, D. M., Johnson, A. L., Tidmarsh, S. F., MacSweeney, D. A., Hewland, H. R., Woolcock, N. E.: Multicompartmental analysis of amino acids: 1. Preliminary data on concentrations, fluxes and flow constants of tryptophan in affective illness. Psychol. Med. 5, 206–213 (1975).Google Scholar
  8. Sneddon, J. M.: Blood platelets as a model for monoamine-containing neurones. Progr. Neurobiol. 1, 151–198 (1973).CrossRefGoogle Scholar
  9. Stahl, S. M.: The human platelet. Arch. gen. Psychiat. 34, 509–516 (1977).PubMedCrossRefGoogle Scholar
  10. Wood, K., Coppen, A.: The effect of clofibrate on total and free plasma tryptophan in depressed patients. Neuropharmacol. 17, 428–430 (1978).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1979

Authors and Affiliations

  • K. Wood
    • 1
  • C. Swade
    • 1
  • A. Coppen
    • 1
  1. 1.MRC Neuropsychiatry LaboratoryWest Park HospitalEpsom, SurreyUK

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