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Transport of Tryptophan and Other Amino Acids by Mammalian Erythrocytes

  • J. D. Young
  • J. C. Ellory
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 15)

Summary

Mammalian erythrocytes are known to have 4 distinct amino acid transport systems. The C system is found in sheep erythrocytes and is specific for neutral amino acids of intermediate size. Human cells lack the C system and have two alternative neutral amino acid transport mechanisms: the L system which is selective for large hydrophobic amino acids and a Na-dependent alanine-cysteine system. The L system is absent from ruminant and cat erythrocytes. Human, rabbit and cat cells, but not sheep erythrocytes, have a specific dibasic amino acid transport mechanism (Ly system). L-Tryptophan uptake by human erythrocytes is mediated by two routes: a saturable high-affinity transport mechanism selective for L-tryptophan and a low affinity uptake mediated by the L system. The saturable component of L-tryptophan transport occurs by a previously unidentified uptake system, and is the major route for L-tryptophan uptake at physiological substrate concentrations. This system is absent from sheep and cat erythrocytes.

Keywords

Human Erythrocyte Amino Acid Transport Neutral Amino Acid Sheep Erythrocyte Amino Acid Transport System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1979

Authors and Affiliations

  • J. D. Young
    • 1
    • 2
  • J. C. Ellory
    • 1
    • 2
  1. 1.ARC Institute of Animal PhysiologyBabraham, CambridgeUK
  2. 2.Physiological LaboratoryCambridgeUK

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