The first detailed morphological description of rat liver peroxisomes was given by Rouiller and Bernhard (1956), who reported on ovoid or round granules with diameters ranging from 0.1 to 0.5 µm. These organelles include a dense, finely granular matrix, are bounded by a single well-defined membrane, and exhibit an opaque, homogeneous core. During the following years these initial observations were confirmed and extended. Rat liver peroxisomes have become the most important objects of morphological and biochemical peroxisome studies. The original description is essentially still valid (Bruni and Porter 1965, Gänsler and Rouiller 1956, Hruban and Rechcigl 1969, Masters and Holmes 1977, Novikoff and Shin 1964, Rouiller and Bernhard 1956, Shnitka 1966, Tsukada et al. 1966).
KeywordsCatalase Activity Acid Oxidase Smooth Endoplasmic Reticulum Peroxisomal Membrane Urate Oxidase
Unable to display preview. Download preview PDF.