In our tour of early emerging metazoans, we have seen that a coral colony may be rooted in a given place, but it is never lonely. There are symbiotic algae and bacteria living in, on, and near it. We also have seen that arranging a simple organism as a metaorganism of several self-coordinating parts can confer fitness and help to sustain periods of changing environmental conditions. We even came to the point to accept that life is fundamental multi-organismal. And we have seen some of the ways holobionts become fragile and break.