The Hidden Impact of Viruses

  • Thomas C. G. Bosch
  • David J. Miller


Metaorganisms have evolved for more than 500 million years, yet only recently have advances in sequencing technology allowed us to appreciate the full nature of the complexities in host–microbe interactions. These technological advances have revealed that in addition to bacteria and associated eukaryotic symbionts, one more important player is an integral member of the holobiont: viruses (Fig. 10.1). Viruses are found anywhere cellular life exists, in any environment or ecosystem. They exist along with their hosts as part of a dynamic community ensemble of exogenous viral particles and endogenous proviruses. Yet, although being the most abundant and diverse biological component on the planet, comparatively little is known about their role in the holobiont. Does the virome play a role in establishing and maintaining the microbiome? What are the underlying mechanisms as to how viruses control microbes? Can bacteriophage-based therapies be used in invertebrates such as corals for treating complex disorders?


Heat Stress Cluster Regularly Interspaced Short Palindromic Repeat Coral Disease Bacteriophage Therapy Short Palindromic Repeat 
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  1. Ben-Haim Y, Rosenberg E (2002) A novel Vibrio. sp. pathogen of the coral Pocillopora damicornis. Mar Biol 141:47–55CrossRefGoogle Scholar
  2. Ben-Haim Y, Zicherman-Keren M, Rosenberg E (2003a) Temperature-regulated bleaching and lysis of the coral Pocillopora damicornis by the novel pathogen Vibrio coralliilyticus. Appl Environ Microbiol 69(7):4236–4242CrossRefPubMedPubMedCentralGoogle Scholar
  3. Ben-Haim Y, Thompson FL, Thompson CC, Cnockaert MC, Hoste B, Swings J, Rosenberg E (2003b) Vibrio coralliilyticus sp. nov., a temperature-dependent pathogen of the coral Pocillopora damicornis. Int J Syst Evol Microbiol 53(Pt 1):309–15CrossRefPubMedGoogle Scholar
  4. Bosch TC, Grasis JA, Lachnit T (2015) Microbial ecology in Hydra: why viruses matter. J Microbiol 53(3):193–200CrossRefPubMedGoogle Scholar
  5. Chanishvili N (2012) Phage therapy-history from Twort and d’Herelle through Soviet experience to current approaches. Adv Virus Res 83:3–40CrossRefPubMedGoogle Scholar
  6. Cohen Y, Pollock F, Rosenberg E, Bourne DG (2013) Phage therapy treatment of the coral pathogen Vibrio coralliilyticus. Microbiologyopen 2(1):64–74CrossRefPubMedPubMedCentralGoogle Scholar
  7. Duerkop B, Hooper LV (2013) Resident viruses and their interactions with the immune system. Nat Immunol 14:654–659CrossRefPubMedPubMedCentralGoogle Scholar
  8. Efrony R, Atad I, Rosenberg E (2008) Phage therapy of coral white plague disease: properties of phage BA3. Curr Microbiol 58:139–145CrossRefPubMedGoogle Scholar
  9. Grasis JA, Lachnit T, Anton-Erxleben F, Lim YW, Schmieder R, Fraune S, Franzenburg S, Insua S, Machado G, Haynes M, Little M, Kimble R, Rosenstiel P, Rohwer FL, Bosch TC (2014) Species-specific viromes in the ancestral holobiont Hydra. PLoS One 9:e109952CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Thomas C. G. Bosch
    • 1
  • David J. Miller
    • 2
  1. 1.Zoological InstituteChristian Albrechts Universitätzu KielKielGermany
  2. 2.ARC Cnt. of Execl. for Coral Reef Stud.James Cook UniversityTownsvilleAustralia

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