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The Challenge of Predicting the Immunotoxic Potential of Chemicals

  • Hans-Werner Vohr
Chapter

Abstract

Well before the mechanisms were understood, pulmonary immune diseases had been associated with environmental chemicals, i.e., air contaminants. During the second half of the twentieth century, purpose and function of the different components of the immune system as well as their interactions with chemicals were extensively investigated and ultimately understood in more detail. In addition to a deeper understanding of immunological interactions and mechanisms, a series of accidents involving immunotoxic compounds pushed the development of immunotoxicological science in the last century.

Keywords

Lymphoid Organ Applicability Domain Local Lymph Node Assay Immunotoxic Effect Cosmetic Directive 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

Thanks go to my esteemed colleague Fred Aswad for his assistance and thoroughly reviewing the manuscript. I like to thank Anna Fischer-Berenbein for providing the basis for two modified figures included here.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  1. 1.Heinrich-Heine-UniversityDüsseldorfGermany

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