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Congenital Heart Diseases: The Broken Heart pp 41–53Cite as

Neural Crest

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Abstract

Cardiac neural crest cells (CNCCs) are a subpopulation of cranial neural crest cells that was first described 30 years ago to be required for cardiac outflow septation. Since then the role of the CNCCs in heart development and congenital heart disease has been explored extensively. This chapter will discuss the contributions of the CNCCs to cardiovascular development, the signaling pathways involved in neural crest development, and some of the human congenital heart diseases attributed to aberrant CNCC development.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, NC, USA

    Bijoy Thattaliyath & Mary Hutson

Authors
  1. Bijoy Thattaliyath
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  2. Mary Hutson
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Corresponding author

Correspondence to Mary Hutson .

Editor information

Editors and Affiliations

  1. Cardiovascular Genetics, Charité - Universitätsmedizin Berlin , Berlin, Germany

    Silke Rickert-Sperling

  2. Developmental Biology, Inst. of Marseilles, Aix-Marseille Univ. , Marseille, France

    Robert G. Kelly

  3. Dpt. of Pediatrics Div.of Pediatric Card, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

    David J. Driscoll

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Thattaliyath, B., Hutson, M. (2016). Neural Crest. In: Rickert-Sperling, S., Kelly, R., Driscoll, D. (eds) Congenital Heart Diseases: The Broken Heart. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1883-2_4

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