Regeneration and Growth as Modes of Adult Development: The Platyhelminthes as a Case Study

  • Francesc Cebrià
  • Emili Saló
  • Teresa Adell


Some species of Platyhelminthes have become model systems in which to study whole-body regeneration in adults. Before describing how this capacity is distributed and varies within the phylum, however, it is important to introduce the adult pluripotent stem cells that confer this remarkable ability in flatworms, the so-called neoblasts.


Ventral Nerve Cord Hippo Pathway Hippo Signalling Ventral Cord Blastema Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Bernhard Egger and Jim Collins and Phil Newmark for providing the images of Macrostomum lignano and Schistosoma mansoni, respectively, used in Fig. 4.4. We thank Miquel Vila-Farré for providing the specimens of Phagocata ullala and Camerata robusta used for the immunostainings shown in Fig. 4.4. We thank Maria Almuedo-Castillo for providing planarian images in Fig. 4.3. We thank Iain Patten for advice on the English. This work was supported by grant BFU2012-31701 (Ministerio de Economía y Competitividad, Spain) to F.C, grant BFU2008-01544 (Ministerio de Economía y Competitividad, Spain) to ES, grant 2009SGR1018 (Agència de Gestió d’Ajuts Universitaris i de Recerca) to ES and FC, and grant AIB2010DE-00402 (Ministerio de Economia y Competitividad Accion Integrada) to ES.


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© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.Department of Genetics, Faculty of BiologyInstitute of Biomedicine, University of BarcelonaCatalunya, BarcelonaSpain

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