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Role of the Pentose Phosphate Pathway in Tumour Metabolism

  • Chapter
Tumor Cell Metabolism

Abstract

The pentose phosphate pathway plays a pivotal role in cellular physiology. It synthesizes the nucleotide precursor ribose-5-phosphate and NADPH, required for redox homeostasis maintenance and lipogenesis. Cancer cells undergo metabolic reprogramming required to sustain proliferation and fully achieve malignant capabilities. Such metabolic reprogramming involves multiple metabolic pathways, and the pentose phosphate pathway becomes essential in tumour metabolism and biology. According to that, many changes occur in this metabolic pathway over the tumorigenic process, and the enzymes in this pathway become directly involved in the metabolism of cancer cells as well as in other important features of tumours. Also, a greater reliance on this pathway has been detected in some types of tumours. In this chapter, a detailed view of the role of the pentose phosphate pathway and its enzymes in tumour metabolism is provided. In addition, the potentiality of this pathway as therapeutic target in cancer treatment is discussed.

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Authors and Affiliations

  1. Facultat de Biologia, Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain

    Adrián Benito, Santiago Diaz-Moralli & Josep J. Centelles

  2. Institute of Biomedicine of the Universitat de Barcelona (IBUB), CSIC Associated Unit, Barcelona, Spain

    Adrián Benito, Santiago Diaz-Moralli, Josep J. Centelles & Marta Cascante

  3. Tavargenix GmbH, Pfungstadt, Germany

    Johannes F. Coy

  4. Tavarlin AG, Pfungstadt, Germany

    Johannes F. Coy

  5. Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Edifici Nou, Planta-2, Avinguda Diagonal 643, Barcelona, 08028, Spain

    Marta Cascante

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  1. Adrián Benito
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  2. Santiago Diaz-Moralli
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  3. Johannes F. Coy
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  4. Josep J. Centelles
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  5. Marta Cascante
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Correspondence to Marta Cascante .

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  1. Inst. of Veterinary Physiology and Bioch, Justus-Liebig-University of Giessen, Gießen, Hessen, Germany

    Sybille Mazurek

  2. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    Maria Shoshan

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Benito, A., Diaz-Moralli, S., Coy, J.F., Centelles, J.J., Cascante, M. (2015). Role of the Pentose Phosphate Pathway in Tumour Metabolism. In: Mazurek, S., Shoshan, M. (eds) Tumor Cell Metabolism. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1824-5_7

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