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Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature

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Developmental Aspects of the Lymphatic Vascular System

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 214))

Abstract

Although the initial event in lymphatic endothelial specification occurs slightly before the initiation of lymph node formation in mice, the development of lymphatic vessels and lymph nodes occurs within the same embryonic time frame. Specification of lymphatic endothelial cells starts around embryonic day 10 (E10), followed by endothelial cell budding and formation of the first lymphatic structures. Through lymphatic endothelial cell sprouting these lymph sacs give rise to the lymphatic vasculature which is complete by E15.5 in mice. It is within this time frame that lymph node formation is initiated and the first structure is secured in place. As lymphatic vessels are crucially involved in the functionality of the lymph nodes, the recent insight that both structures depend on common developmental signals for their initiation provides a molecular mechanism for their coordinated formation. Here, we will describe the common developmental signals needed to properly start the formation of lymphatic vessels and lymph nodes and their interdependence in adult life.

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Authors and Affiliations

  1. Royal Netherlands Academy of Arts and Sciences, Hubrecht Institute, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands

    Serge A. van de Pavert

  2. Department of Molecular Cell Biology and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081BT, Amsterdam, The Netherlands

    Reina E. Mebius

Authors
  1. Serge A. van de Pavert
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  2. Reina E. Mebius
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Correspondence to Reina E. Mebius .

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Editors and Affiliations

  1. MPI for Molecular Biomedicine, Münster, Germany

    Friedemann Kiefer

  2. Hubrecht Institute, Utrecht, The Netherlands

    Stefan Schulte-Merker

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van de Pavert, S.A., Mebius, R.E. (2014). Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature. In: Kiefer, F., Schulte-Merker, S. (eds) Developmental Aspects of the Lymphatic Vascular System. Advances in Anatomy, Embryology and Cell Biology, vol 214. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1646-3_7

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  • DOI: https://doi.org/10.1007/978-3-7091-1646-3_7

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  • Print ISBN: 978-3-7091-1645-6

  • Online ISBN: 978-3-7091-1646-3

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