Sleep Disordered Breathing in Parkinson’s Disease
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Sleep disordered breathing (SDB) is a serious medical condition in which there are repeated reductions or cessations of breathing during sleep. Early research suggested that because Parkinson’s disease (PD) patients have pulmonary abnormalities while they are awake they may be at increased risk for developing sleep disordered breathing. A large literature now demonstrates that sleep disordered breathing is common in Parkinson’s disease patients, but no different than age-matched controls from the general population. In the general population, sleep disordered breathing often correlates with excessive daytime sleepiness, but this correlation is not typically observed within Parkinson’s disease patients. However, sleep disordered breathing in Parkinson’s disease has been preliminarily linked to impaired sleep-dependent memory consolidation, blunted sympathetic responses, and worsening motor function Unified Parkinson’s Disease Rating Scale (UPDRS). Parkinson’s disease patients who have sleep disordered breathing may benefit from positive airway pressure or mandibular advancement treatments, and an exciting avenue for future research is determining whether such treatment also positively affects disease progression and quality of life.
KeywordsObstructive Sleep Apnea Obstructive Sleep Apnea Syndrome Sleep Disorder Breathing Excessive Daytime Sleepiness Berlin Questionnaire
Preparation of this chapter was supported by funding from the National Institute on Health (grant numbers 1P50NS071669 and F32AG041543). M.K.S. was partially supported by an Emory University School of Medicine Cottrell Fellowship.
- 8.Iber C, Ancoli-Israel S, Chesson AL, et al. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. Westchester: American Academy of Sleep Medicine; 2007.Google Scholar
- 46.Nomura T, Inoue Y, Kobayashi M, et al. Characteristics of obstructive sleep apnea in patients with Parkinson’s disease. J Neurol Sci. 2013.Google Scholar
- 57.Scullin MK, Fairley JA, Trotti LM, et al. Sleep correlates of trait executive function and memory in Parkinson’s disease. J Parkinsons Dis. 2015;5:49–54.Google Scholar
- 61.Terpening Z, Naismith S, Melehan K, et al. The contribution of nocturnal sleep to the consolidation of motor skill learning in healthy ageing and Parkinson’s disease. J Sleep Res. 2013.Google Scholar
- 65.Scullin MK, Trotti LM, Goldstein FC et al. PSG-recorded sleep as a possible biomarker of worsening motor function in Parkinson’s disease. In: Abstracts of the annual SLEEP meeting, Baltimore, June 2013.Google Scholar
- 69.Neikrug AB, Liu L, Avanzino JA, et al. Continuous positive airway pressure improves sleep and daytime sleepiness in patients with Parkinson’s disease and sleep apnea. Sleep. 2014;37:177–85.Google Scholar