Impaired Sleep and Alertness in Parkinson’s Disease: “What Did We Learn from Animal Models?”

  • Pierre-Hervé LuppiEmail author
  • Olivier Clément
  • Sara Valencia Garcia
  • Frédéric Brischoux
  • Patrice Fort


The aim of this review is to try to provide a conceptual framework on the mechanisms potentially responsible for sleep alteration in Parkinson’s disease (PD) based on data obtained in animals. We first provide state-of-the-art hypotheses on the mechanisms responsible for the succession of the three vigilance states, namely waking, non-rapid eye movement (non-REM) also called slow-wave sleep (SWS) and REM sleep also called paradoxical sleep (PS). We then review our knowledge on the role of dopamine in sleep-waking regulation. We pursue by discussing the results obtained on sleep in MPTP animal model of PD. We complete our review by providing hypotheses on the mechanisms responsible for REM sleep behavior disorder known to occur in half of the Parkinson’s patients based on studies of RBD animal models.


Parkinson Brainstem Glycine GABA 



This work was supported by CNRS, Fondation France Parkinson and University Claude Bernard of Lyon.


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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Pierre-Hervé Luppi
    • 1
    • 2
    • 3
    • 4
    Email author
  • Olivier Clément
    • 1
    • 2
    • 3
  • Sara Valencia Garcia
    • 1
    • 2
    • 3
  • Frédéric Brischoux
    • 1
    • 2
    • 3
  • Patrice Fort
    • 1
    • 2
    • 3
  1. 1.“SLEEP” teamINSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team Physiopathologie des réseaux neuronaux du cycle veille-sommeilLyonFrance
  2. 2.University of LyonLyonFrance
  3. 3.University Claude Bernard Lyon 1LyonFrance
  4. 4.Faculté de Médecine RTH LaennecUMR5167 CNRSLyonFrance

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