Impact of Surgical Therapies on Sleep and Alertness in Parkinson’s Disease

  • Amy W. AmaraEmail author
  • Harrison C. Walker


Surgical therapies for Parkinson’s disease (PD) play an increasingly important role in the treatment of motor symptoms that are refractory to medical management. These therapies include deep brain stimulation, lesional/ablation surgery of brain structures, and placement of an intrajejunal tube to administer continuous drug delivery of levodopa/carbidopa intestinal gel (LCIG). Sleep dysfunction and excessive daytime sleepiness are very common among patients with Parkinson’s disease and negatively impact quality of life. For this reason, understanding the impact of surgical therapies on these symptoms can provide additional insights into strategies for optimizing outcomes and provide a better understanding of the pathophysiology of sleep disorders in PD patients. In this chapter, we review the available data on the effects of surgical therapies on sleep architecture, sleep quality, and daytime vigilance and discuss the need for further study to fully understand the mechanisms underlying changes in sleep following surgical intervention.


Sleep Quality Deep Brain Stimulation Essential Tremor Sleep Architecture Globus Pallidus Internal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported in part by the Francis and Ingeborg Heide Schumann Fellowship in Parkinson’s Disease Research (AA) and the Sartain Lanier Family Foundation (HW), and grant funding from the NIH NINDS K23NS080912 (AW) and NIH NINDS K23NS067053 (HW), and the American Sleep Medicine Foundation (AW). We would also like to sincerely thank Anthony Nicholas for contributing the content of Fig. 15.1.


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Authors and Affiliations

  1. 1.Division of Movement Disorders, Department of Neurology, UAB Sleep/Wake Disorders CenterUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Division of Movement Disorders, Department of NeurologyUniversity of Alabama at BirminghamBirminghamUSA

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