Regulation of Sleep and Wake Homeostasis

  • Cathy A. GoldsteinEmail author
  • Ronald D. Chervin


The interaction of two opposing processes, the circadian rhythm and homeostatic sleep drive, governs sleep and wake. Circadian timing promotes alertness during the environmental day and sleep during the environmental night, while the homeostatic sleep drive grows with cumulative wakefulness independent of time. Homeostatic sleep drive is measured by its electroencephalogram correlate, slow-wave activity. Slow-wave activity increases not only in response to prolonged wakefulness, but also demonstrates spatial organization and increases in a local, use-dependent pattern based on previous physical and mental activity. These findings support the important hypothesis that sleep mediates homeostasis of neuronal synapses. Therefore, the homeostatic control of sleep and wake has implications that extend beyond alertness.


Sleep Deprivation Sleep Duration NREM Sleep Recovery Sleep Sleep Homeostasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Borbely AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1(3):195–204.PubMedGoogle Scholar
  2. 2.
    Daan S, Beersma DG, Borbély AA. Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol. 1984;246(2):R161–83.PubMedGoogle Scholar
  3. 3.
    Wyatt JK, Ritz-De Cecco A, Czeisler CA, Dijk DJ. Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. Am J Physiol. 1999;277:R1152–63.PubMedGoogle Scholar
  4. 4.
    Edgar DM, Dement WC, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci. 1993;13(3):1065–79.PubMedGoogle Scholar
  5. 5.
    Lavie P. Ultrashort sleep-waking schedule. III. ‘Gates’ and ‘forbidden zones’ for sleep. Electroencephalogr Clin Neurophysiol. 1986;63(5):414–25.PubMedGoogle Scholar
  6. 6.
    Lavie P. Melatonin: role in gating nocturnal rise in sleep propensity. J Biol Rhythms. 1997;12(6):657–65.PubMedGoogle Scholar
  7. 7.
    Dijk DJ, Czeisler CA. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci Lett. 1994;166(1):63–8.PubMedGoogle Scholar
  8. 8.
    Cannon WB. The wisdom of the body. New York: Norton & Co., Inc.; 1932. Print. Google Scholar
  9. 9.
    Borberly AA. Sleep: circadian rhythm versus recovery process. In: Koukkou M, Lehmann D, Angst J, editors. Functional states of the brain. Their determinants. Amsterdam: Elsevier; 1980. p. 151–61.Google Scholar
  10. 10.
    Berger H. Ueber das Elektroenkephalogramm des Menschen. J Psychol Neurol. 1930;40:160–79.Google Scholar
  11. 11.
    Loomis AL, Harvey EN, Hobart G. Cerebral states during sleep, as studied by human brain potentials. J Exp Psychol. 1937;21:127–44.Google Scholar
  12. 12.
    Davis H, Davis P, Loomis A, Harvey E, Hobart G. Changes in human brain potentials during the onset of sleep. Science. 1937;86(2237):448–50.PubMedGoogle Scholar
  13. 13.
    Blake H, Gerard RW. Brain potentials during sleep. Am J Physiol. 1937;119:692–703.Google Scholar
  14. 14.
    Williams HL, Hammack JT, Day RL, Dement WC, Lubin A. Responses to auditory stimulation, sleep loss, and the EEG stages of sleep. Electroencephalogr Clin Neurophysiol. 1964;16:269–79.PubMedGoogle Scholar
  15. 15.
    Aserinsky E, Klietman N. Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science. 1953;118(3062):273–4.PubMedGoogle Scholar
  16. 16.
    Dement W, Kleitman N. Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalogr Clin Neurophysiol. 1957;9(4):673–90.PubMedGoogle Scholar
  17. 17.
    Berry RB, Brooks R, Gamaldo CE, Harding SM, Marcus CL, Vaughn BV, American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 2.0.1. Darien: American Academy of Sleep Medicine; 2013.Google Scholar
  18. 18.
    Borberly AA, Baumann F, Brandeis D, et al. Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol. 1981;51:483–93.Google Scholar
  19. 19.
    McCormick DA, Bal T. Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci. 1997;20:185–215.PubMedGoogle Scholar
  20. 20.
    McCormick DA. Cortical and subcortical generators of normal and abnormal rhythmicity. Int Rev Neurobiol. 2002;49:99–114.PubMedGoogle Scholar
  21. 21.
    McGinty D, Szymusiak R. Brain structures and mechanisms involved in the generation of NREM sleep: focus on the preoptic hypothalamus. Sleep Med Rev. 2001;5(4):323–42.PubMedGoogle Scholar
  22. 22.
    Gaus SE, Strecker RE, Tate BA, Parker RA, Saper CB. Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species. Neuroscience. 2002;115(1):285–94.PubMedGoogle Scholar
  23. 23.
    Sherin JE, Shiromani PJ, McCarley RW, Saper CB. Activation of ventrolateral preoptic neurons during sleep. Science. 1996;271(5246):216–9.PubMedGoogle Scholar
  24. 24.
    Sherin JE, Elmquist JK, Torrealba F, Saper CB. Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci. 1998;18(12):4705–21.PubMedGoogle Scholar
  25. 25.
    Steininger TL, Gong H, McGinty D, Szymusiak R. Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J Comp Neurol. 2001;429(4):638–53.PubMedGoogle Scholar
  26. 26.
    Gong H, McGinty D, Guzman-Marin R, Chew KT, Stewart D, Szymusiak R. Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation. J Physiol. 2004;556:935–46.PubMedCentralPubMedGoogle Scholar
  27. 27.
    Uschakov A, Gong H, McGinty D, Szymusiak R. Efferent projections from the median preoptic nucleus to sleep- and arousal-regulatory nuclei in the rat brain. Neuroscience. 2007;150(1):104–20.PubMedCentralPubMedGoogle Scholar
  28. 28.
    Szymusiak R, Alam N, Steininger TL, McGinty D. Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats. Brain Res. 1998;803(1–2):178–88.PubMedGoogle Scholar
  29. 29.
    Takahashi K, Lin JS, Sakai K. Characterization and mapping of sleep-waking specific neurons in the basal forebrain and preoptic hypothalamus in mice. Neuroscience. 2009;161(1):269–92.PubMedGoogle Scholar
  30. 30.
    Saper CB, Chou TC, Scammel TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;12:726–31.Google Scholar
  31. 31.
    Obal Jr F, Krueger JM. Biochemical regulation of non-rapid-eye-movement sleep. Front Biosci. 2003;8:d520–50.PubMedGoogle Scholar
  32. 32.
    Ram A, Pandey HP, Matsumura HP, et al. CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. Brain Res. 1997;751:81–9.PubMedGoogle Scholar
  33. 33.
    Benington JH, Heller HC. Restoration of brain energy metabolism as a function of sleep. Prog Neurobiol. 1995;45(4):347–60.PubMedGoogle Scholar
  34. 34.
    Porkka-Heiskanen T, Strecker RE, Thakkar M, et al. Adenosine: a mediator of the sleep inducing effects of prior wakefulness. Science. 1997;276:1265–8.PubMedCentralPubMedGoogle Scholar
  35. 35.
    Benington JH, Kodali SK, Heller HC. Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation. Brain Res. 1995;692:79–85.PubMedGoogle Scholar
  36. 36.
    Fredholm B, Battig K, Holmen J, Nehlig A, Zvartau E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83–133.PubMedGoogle Scholar
  37. 37.
    Webb WB, Agnew Jr HW. Stage 4 sleep: influence of time course variables. Science. 1971;174(4016):1354–6.PubMedGoogle Scholar
  38. 38.
    Weitzman ED, Czeisler CA, Zimmerman JC, Ronda JM. Timing of REM and stages 3 + 4 sleep during temporal isolation in man. Sleep. 1980;2(4):391–407.PubMedGoogle Scholar
  39. 39.
    Dijk DJ, Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci. 1995;15(5 Pt 1):3526–38.PubMedGoogle Scholar
  40. 40.
    Karacan I, Finley W, Williams R, Hursch C. Changes in stage 1-REM and stage 4 sleep during naps. Biol Psychiatry. 1970;2:261–5.PubMedGoogle Scholar
  41. 41.
    Maron L, Rechtschaffen A, Wolpert E. Sleep cycle during napping. Arch Gen Psychiatry. 1964;11:503–7.PubMedGoogle Scholar
  42. 42.
    Dijk DJ, Beersma DG, Daan S, Bloem GM, Van den Hoofdakker RH. Quantitative analysis of the effects of slow wave sleep deprivation during the first 3 h of sleep on subsequent EEG power density. Eur Arch Psychiatry Neurol Sci. 1987;236(6):323–8.PubMedGoogle Scholar
  43. 43.
    Karacan I, Williams R, Finley W, Hursch C. The effects of naps on nocturnal sleep: influence on the need for stage 1-REM and stage 4 sleep. Biol Psychiatry. 1970;2:397–9.Google Scholar
  44. 44.
    Feinberg I, March J, Floyd T, et al. Homeostatic changes during post-nap sleep maintain baseline levels of delta EEG. Electroencephalogr Clin Neurophysiol. 1985;61:134–7.PubMedGoogle Scholar
  45. 45.
    Werth E, Dijk DJ, Achermann P, Borbély AA. Dynamics of the sleep EEG after an early evening nap: experimental data and simulations. Am J Physiol. 1996;271:501–10.Google Scholar
  46. 46.
    Webb WB, Agnew Jr HW. Sleep: effects of a restricted regime. Science. 1965;150(3704):1745–7.PubMedGoogle Scholar
  47. 47.
    Dijk DJ, Brunner DP, Beersma DG, Borbély AA. Electroencephalogram power density and slow wave sleep as a function of prior waking and circadian phase. Sleep. 1990;13(5):430–40.PubMedGoogle Scholar
  48. 48.
    Dijk DJ, Hayes B, Czeisler CA. Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation. Brain Res. 1993;626(1–2):190–9.PubMedGoogle Scholar
  49. 49.
    Aeschbach D, Cajochen C, Landolt H, Borbély AA. Homeostatic sleep regulation in habitual short sleepers and long sleepers. Am J Physiol. 1996;270(1 Pt 2):R41–53.PubMedGoogle Scholar
  50. 50.
    Agnew HW, Webb WB. The displacement of stages 4 and REM sleep within a full night of sleep. Psychophysiology. 1968;5:142–8.PubMedGoogle Scholar
  51. 51.
    Ferrara M, De Gennaro L, Curcio G, Cristiani R, Corvasce C, Bertini M. Regional differences of the human sleep electroencephalogram in response to selective slow-wave sleep deprivation. Cereb Cortex. 2002;12(7):737–48.PubMedGoogle Scholar
  52. 52.
    Werth E, Achermann P, Borbély AA. Fronto-occipital EEG power gradients in human sleep. J Sleep Res. 1997;6(2):102–12.PubMedGoogle Scholar
  53. 53.
    Finelli LA, Borbély AA, Achermann P. Functional topography of the human nonREM sleep electroencephalogram. Eur J Neurosci. 2001;13(12):2282–90.PubMedGoogle Scholar
  54. 54.
    Cajochen C, Foy R, Dijk DJ. Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans. Sleep Res Online. 1999;2(3):65–9.PubMedGoogle Scholar
  55. 55.
    Horne JA, Moore VJ. Sleep EEG effects of exercise with and without additional body cooling. Electroencephalogr Clin Neurophysiol. 1985;60(1):33–8.PubMedGoogle Scholar
  56. 56.
    Horne JA, Minard A. Sleep and sleepiness following a behaviourally ‘active’ day. Ergonomics. 1985;28(3):567–75.PubMedGoogle Scholar
  57. 57.
    Naylor E, Penev PD, Orbeta L, Janssen I, Ortiz R, Colecchia EF, Keng M, Finkel S, Zee PC. Daily social and physical activity increases slow-wave sleep and daytime neuropsychological performance in the elderly. Sleep. 2000;23(1):87–95.PubMedGoogle Scholar
  58. 58.
    Kattler H, Dijk D, Borbely A. Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans. J Sleep Res. 1994;3:159–64.PubMedGoogle Scholar
  59. 59.
    Huber R, Ghilardi MF, Massimini M, Ferrarelli F, Riedner BA, Peterson MJ, Tononi G. Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity. Nat Neurosci. 2006;9(9):1169–76.PubMedGoogle Scholar
  60. 60.
    Huber R, Ghilardi MF, Massimini M, Tononi G. Local sleep and learning. Nature. 2004;430(6995):78–81.PubMedGoogle Scholar
  61. 61.
    Tononi G, Cirelli C. Sleep function and synaptic homeostasis. Sleep Med Rev. 2006;10(1):49–62.PubMedGoogle Scholar
  62. 62.
    Tononi G, Cirelli C. Time to be SHY/Some comments on sleep and synaptic homeostasis. Neural Plast. 2012. Volume 2012, Article ID 415250, 12 pages.Google Scholar
  63. 63.
    Coble PA, Reynolds III CF, Kupfer DJ, Houck P. Electroencephalographic sleep of healthy children. Part II: findings using automated delta and REM sleep measurement methods. Sleep. 1987;10(6):551–62.PubMedGoogle Scholar
  64. 64.
    Feinberg I, Carlson VR. Sleep variables as a function of age in man. Arch Gen Psychiatry. 1968;18:239–50.Google Scholar
  65. 65.
    Feinberg I. Changes in sleep cycle patterns with age. J Psychiatr Res. 1974;10:283–306.PubMedGoogle Scholar
  66. 66.
    Feinberg I, March JD, Flach K, Maloney T, Chern W-J, Travis F. Maturational changes in amplitude, incidence and cyclic pattern of the 0 to 3 Hz (delta) electroencephalogram of human sleep. Brain Dysfunct. 1990;3:183–92.Google Scholar
  67. 67.
    Gaudreau H, Carrier J, Montplaisir J. Age-related modifications of NREM sleep EEG: from childhood to middle age. J Sleep Res. 2001;10:165–72.PubMedGoogle Scholar
  68. 68.
    Jenni OG, Carskadon MA. Spectral analysis of the sleep electroencephalogram during adolescence. Sleep. 2004;27:774–83.PubMedGoogle Scholar
  69. 69.
    Campbell IG, Feinberg I. Longitudinal trajectories of non-rapid eye movement delta and theta EEG as indicators of adolescent brain maturation. Proc Natl Acad Sci U S A. 2009;106:5177–80.PubMedCentralPubMedGoogle Scholar
  70. 70.
    Campbell IG, Darchia N, Higgins LM, Dykan IV, Davis NM, de Bie E, Feinberg I. Adolescent changes in homeostatic regulation of EEG activity in the delta and theta frequency bands during NREM sleep. Sleep. 2011;34(1):83–91.PubMedCentralPubMedGoogle Scholar
  71. 71.
    Bliwise DL. Sleep in normal aging and dementia. Sleep. 1993;16(1):40–81.PubMedGoogle Scholar
  72. 72.
    Bonnet MH. Recovery of performance during sleep following sleep deprivation in older normal and insomniac adult males. Percept Mot Skills. 1985;60:323–34.PubMedGoogle Scholar
  73. 73.
    Bonnet MH, Rosa RR. Sleep and performance in young adults and older normals and insomniacs during acute sleep loss andrecovery. Biol Psychol. 1987;25:153–72.PubMedGoogle Scholar
  74. 74.
    Bonnet MH. The effect of sleep fragmentation on sleep and performance in younger and older subjects. Neurobiol Aging. 1989;10:21–5.PubMedGoogle Scholar
  75. 75.
    Brendel DH, Reynolds CF, Jennings JR, Hoch CC, Monk TH, Berman SR, Hall FT, Buyssee DJ, Kupfer DJ. Sleep stage physiology, mood, and vigilance responses to total sleep deprivation in healthy 80 year olds and 20 year olds. Psychophysiology. 1990;27(6):677–84.PubMedGoogle Scholar
  76. 76.
    Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP. Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. Nat Neurosci. 2013;16(3):357–64.PubMedCentralPubMedGoogle Scholar
  77. 77.
    Rétey JV, Adam M, Honegger E, Khatami R, Luhmann UF, Jung HH, Berger W, Landolt HP. A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A. 2005;102(43):15676–81.PubMedCentralPubMedGoogle Scholar
  78. 78.
    Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex. 2012;22(4):962–70.PubMedGoogle Scholar
  79. 79.
    Mazzotti DR, Guindalini C, de Souza AA, Sato JR, Santos-Silva R, Bittencourt LR, Tufik S. Adenosine deaminase polymorphism affects sleep EEG spectral power in a large epidemiological sample. PLoS One. 2012;7(8):e44154.PubMedCentralPubMedGoogle Scholar
  80. 80.
    Bachmann V, Klein C, Bodenmann S, Schäfer N, Berger W, Brugger P, Landolt HP. The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity. Sleep. 2012;35:335–44.PubMedCentralPubMedGoogle Scholar
  81. 81.
    Laposky A, Easton A, Dugovic C, Walisser J, Bradfield C, Turek F. Deletion of the mammalian circadian clock gene BMAL/Mop3 alters baseline sleep architecture and the response to sleep deprivation. Sleep. 2005;28(4):395–409.PubMedGoogle Scholar
  82. 82.
    Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH, Turek FW. The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci. 2000;20(21):8138–43.PubMedGoogle Scholar
  83. 83.
    Wisor JP, O’Hara BF, Terao A, Selby CP, Kilduff TS, Sancar A, Edgar DEM, Franken P. A role cryptochromes in sleep regulation. BMC Neurosci. 2002;3(20):1–14.Google Scholar
  84. 84.
    Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O'Harar BF, McKnight SL. NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci. 2006;103(18):7118–23.PubMedCentralPubMedGoogle Scholar
  85. 85.
    Shaw PJ, Tononi G, Greenspan RJ, Robinson DF. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 2002;417(6886):287–91.PubMedGoogle Scholar
  86. 86.
    Franken P, Thomason R, Heller HC, O’Hara BF. A non-circadian role for clock-genes in sleep homeostasis: a strain comparison. BMC Neurosci. 2007;8:87.PubMedCentralPubMedGoogle Scholar
  87. 87.
    Viola AU, Archer SN, James LM, Groeger JA, Lo JC, Skene DJ, von Schantz M, Dijk DJ. PER3 polymorphism predicts sleep structure and waking performance. Curr Biol. 2007;17(7):613–8.PubMedGoogle Scholar
  88. 88.
    Archer SN, Robilliard DL, Skene DJ, et al. A length polymorphism n the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep. 2003;26(4):413–5.PubMedGoogle Scholar
  89. 89.
    He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder Jr JL, Rossner MJ, Nishino S, Fu YH. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009;325(5942):866–70.PubMedCentralPubMedGoogle Scholar
  90. 90.
    Centers for Disease Control and Prevention (CDC). Effect of short sleep duration on daily activities - United States, 2005-2008. MMWR Morb Mortal Wkly Rep. 2011;60:239–52.Google Scholar
  91. 91.
    Rupp TL, Wesensten NJ, Bliese PD, Balkin TJ. Banking sleep: realization of benefits during subsequent sleep restriction and recovery. Sleep. 2009;32(3):311–21.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Drake CL, Roehrs T, Richardson G, et al. Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers. Sleep. 2004;27(8):1453–62.PubMedGoogle Scholar
  93. 93.
    Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, Klerman EB. Uncovering residual effects of chronic sleep loss on human performance. Sci Transl Med. 2010;2(14):14ra3.PubMedCentralPubMedGoogle Scholar
  94. 94.
    Zhou X, Ferguson SA, Mathews RW, et al. Sleep, wake, and phase dependent changes in neurobehavioral function under forced desynchrony. Sleep. 2011;34:931–41.PubMedCentralPubMedGoogle Scholar
  95. 95.
    Schweitzer PK, Randazzo AC, Stone K, Erman M, Walsh JK. Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work. Sleep. 2006;29:39–50.PubMedGoogle Scholar
  96. 96.
    Sallinen M, Harma M, Akerstedt T, Rosa R, Lillqvist O. Promoting alertness with a short nap during a night shift. J Sleep Res. 1998;7:240–7.PubMedGoogle Scholar
  97. 97.
    Purnell MT, Feyer AM, Herbison GP. The impact of a nap opportunity during the night shift on the performance and alertness of 12-h shift workers. J Sleep Res. 2002;11(3):219–27.PubMedGoogle Scholar
  98. 98.
    Garbarino S, Mascialino B, Penco MA, et al. Professional shift-work drivers who adopt prophylactic naps can reduce the risk of car accidents during night work. Sleep. 2004;27:1295–302.PubMedGoogle Scholar
  99. 99.
    Bonnefond A, Muzet A, Winter-Dill AS, Bailloeuil C, Bitouze F, Bonneau A. Innovative working schedule: introducing one short nap during the night shift. Ergonomics. 2001;44:937–45.PubMedGoogle Scholar
  100. 100.
    Vernet C, Arnulf I. Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients. Sleep. 2009;32(6):753–9.PubMedCentralPubMedGoogle Scholar
  101. 101.
    Weitzman ED, Czeisler CA, Coleman RM, et al. Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia. Arch Gen Psychiatry. 1981;38(7):737–46.PubMedGoogle Scholar
  102. 102.
    American Academy of Sleep Medicine. The international classification of sleep disorders: diagnostic and coding manual. 2nd ed. Westchester: American Academy of Sleep Medicine; 2005.Google Scholar
  103. 103.
    Ozaki S, Uchiyama M, Shirakawa S, et al. Prolonged interval from body temperature nadir to sleep off set in patients with delayed sleep phase syndrome. Sleep. 1996;19(1):36–40.PubMedGoogle Scholar
  104. 104.
    Watanabe T, Kajimura N, Kato M, et al. Sleep and circadian rhythm disturbances in patients with delayed sleep phase syndrome. Sleep. 2003;26(6):657–61.PubMedGoogle Scholar
  105. 105.
    Cole RJ, Smith JS, Alcala YC, et al. Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythms. 2002;17:89–101.PubMedGoogle Scholar
  106. 106.
    Campbell SS, Murphy PJ. Delayed sleep phase disorder in temporal isolation. Sleep. 2007;30(9):1225–8.PubMedCentralPubMedGoogle Scholar
  107. 107.
    Uchiyama M, Okawa M, Shibui K, et al. Poor compensatory function for sleep loss as a pathogenic factor in patients with delayed sleep phase syndrome. Sleep. 2000;23(4):553–8.PubMedGoogle Scholar
  108. 108.
    Uchiyama M, Shibui K, Hayakawa T, et al. Larger phase angle between sleep propensity and melatonin rhythms in sighted humans with non-24-hour sleep-wake syndrome. Sleep. 2002;25:83–8.PubMedGoogle Scholar
  109. 109.
    Hayakawa T, Uchiyama M, Kamei Y, et al. Clinical analyses of sighted patients with non- 24-hour sleep-wake syndrome: a study of 57 consecutively diagnosed cases. Sleep. 2005;28(8):945–52.PubMedGoogle Scholar
  110. 110.
    Okawa M, Uchiyama M. Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome. Sleep Med Rev. 2007;11(6):485–96.PubMedGoogle Scholar
  111. 111.
    Mongrain V, Dumont M. Increased homeostatic response to behavioral sleep fragmentation in morning types compared to evening types. Sleep. 2007;30(6):773–80.PubMedCentralPubMedGoogle Scholar
  112. 112.
    Taillard J, Philip P, Coste O, Sagaspe P, Bioulac B. The circadian and homeostatic modulation of sleep pressure during wakefulness differs between morning and evening chronotypes. J Sleep Res. 2003;12:275–82.PubMedGoogle Scholar
  113. 113.
    Lancel M, Kerkhof GA. Sleep structure and EEG power density in morning types and evening types during a simulated day and night shift. Physiol Behav. 1991;49:1195–201.PubMedGoogle Scholar
  114. 114.
    Mongrain V, Carrier J, Dumont M. Difference in sleep regulation between morning and evening circadian types as indexed by antero-posterior analyses of the sleep EEG. Eur J Neurosci. 2006;23(2):497–504.PubMedGoogle Scholar
  115. 115.
    Schmidt C, Collette F, Leclercq Y, Sterpenich V, Vandewalle G, et al. Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Science. 2009;324:516–9.PubMedGoogle Scholar
  116. 116.
    Chang AM, Reid KJ, Gourineni R, et al. Sleep timing and circadian phase in delayed sleep phase syndrome. J Biol Rhythms. 2009;24(4):313–21.PubMedCentralPubMedGoogle Scholar

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Authors and Affiliations

  1. 1.University of Michigan Health System Sleep Disorders CenterAnn ArborUSA

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