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Regulation of Sleep and Wake Homeostasis

  • Cathy A. GoldsteinEmail author
  • Ronald D. Chervin
Chapter
  • 1.1k Downloads

Abstract

The interaction of two opposing processes, the circadian rhythm and homeostatic sleep drive, governs sleep and wake. Circadian timing promotes alertness during the environmental day and sleep during the environmental night, while the homeostatic sleep drive grows with cumulative wakefulness independent of time. Homeostatic sleep drive is measured by its electroencephalogram correlate, slow-wave activity. Slow-wave activity increases not only in response to prolonged wakefulness, but also demonstrates spatial organization and increases in a local, use-dependent pattern based on previous physical and mental activity. These findings support the important hypothesis that sleep mediates homeostasis of neuronal synapses. Therefore, the homeostatic control of sleep and wake has implications that extend beyond alertness.

Keywords

Sleep Deprivation Sleep Duration NREM Sleep Recovery Sleep Sleep Homeostasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.University of Michigan Health System Sleep Disorders CenterAnn ArborUSA

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