Abstract
The prevalence and incidence of MG have increased over the years, especially in elderly men. Current estimates are 0.17–1.04/100,000 for incidence and 0.3–20/100,000 for prevalence. MuSK-Ab-positive MG commonly affects women.
Coexisting autoimmune diseases are frequent in MG with autoimmune thyroid disease being the most common. Autoimmune diseases occur more often in female and seronegative patients.
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References
Myasthenia Gravis
Gilhus NE, Owe JF, Hoff JM, Romi F, Skeie GO, Aarli JA (2011) Myasthenia gravis: a review of available treatment approaches. Autoimmune Dis 2011:847393
Guptill JT, Sanders DB (2010) Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis. Curr Opin Neurol 23:530–535
Jacob S, Viegas S, Lashley D, Hilton-Jones D (2009) Myasthenia gravis and other neuromuscular junction disorders. Pract Neurol 9:364–371
Jaretzki A, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS, Sanders DB (2000) Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology 55(1):16–23
Pasnoor M, Wolfe GI, Nations S, Trivedi J, Barohn RJ, Herbelin L, McVey A, Dimachkie M, Kissel J, Walsh R, Amato A, Mozaffar T, Hungs M, Chui L, Goldstein J, Novella S, Burns T, Phillips L, Claussen G, Young A, Bertorini T, Oh S (2010) Clinical findings in MuSK-antibody positive myasthenia gravis: a U.S. experience. Muscle Nerve 41:370–374
Spillane J, Beeson DJ, Kullmann DM (2010) Myasthenia and related disorders of the neuromuscular junction. J Neurol Neurosurg Psychiatry 81:850–857
Vincent A (2006) Immunology of disorders of neuromuscular transmission. Acta Neurol Scand 113(Suppl 183):1–7
Congenital Myasthenic Syndromes
Alseth EH, Maniaol AH, Elsais A, Nakkestad HL, Tallaksen C, Gilhus NE, Skeie GO (2011) Investigation for RAPSN and DOK-7 mutations in a cohort of seronegative myasthenia gravis patients. Muscle Nerve 43:574–577
Engel AG (2012) Current status of the congenital myasthenic syndromes. Neuromuscul Disord 22:99–111
Harper CM (2004) Congenital myasthenic syndromes. Semin Neurol 24:111–123
Palace J, Lashley D, Bailey S, Jayawant S, Carr A, Mcconville J, Robb S, Beeson D (2012) Clinical features in a series of fast channel congenital myasthenia syndrome. Neuromuscul Disord 22:112–117
Schara U, Lochmüller H (2008) Therapeutic strategies in congenital myasthenic syndromes. Neurotherapeutics 5:542–547
Lambert-Eaton Myasthenic Syndrome (LEMS)
Hatanaka Y, Oh SJ (2008) Ten-second exercise is superior to 30-second exercise for post-exercise facilitation in diagnosing Lambert-Eaton myasthenic syndrome. Muscle Nerve 37:572–575
Petty R (2007) Lambert Eaton myasthenic syndrome. Pract Neurol 7:265–267
Spillane J, Beeson DJ, Kullmann DM (2010) Myasthenia and related disorders of the neuromuscular junction. J Neurol Neurosurg Psychiatry 81:850–857
Titulaer MJ, Wirtz PW, Kuks JB, Schelhaas HJ, van der Kooi AJ, Faber CG, van der Pol WL, de Visser M, Sillevis Smitt PA, Verschuuren JJ (2008) The Lambert-Eaton myasthenic syndrome 1988–2008: a clinical picture in 97 patients. J Neuroimmunol 201–202:153–158
Titulaer MJ, Maddison P, Sont JK, Wirtz PW, Hilton-Jones D, Klooster R, Willcox N, Potman M, Sillevis Smitt PA, Kuks JB, Roep BO, Vincent A, van der Maarel SM, van Dijk JG, Lang B, Verschuuren JJ (2011) Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS. J Clin Oncol 29:902–908
Botulism
Dembek ZF, Smith LA, Rusnak JM (2007) Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities. Disaster Med Public Health Prep 1:122–134
Hart IK, Maddison P, Newsom-Davis J, Vincent A, Mills KR (2002) Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 125:1887–1895
Löscher WN, Wanschitz J, Reiners K, Quasthoff S (2004) Morvan’s syndrome: clinical, laboratory, and in vitro electrophysiological studies. Muscle Nerve 30:157–163
Merchut MP (2010) Management of voltage-gated potassium channel antibody disorders. Neurol Clin 28:941–959
Neuromyotonia (Isaacs’ Syndrome)
Rubio-Agusti I, Perez-Miralles F, Sevilla T, Muelas N, Chumillas MJ, Mayordomo F, Azorin I, Carmona E, Moscardo F, Palau J, Jacobson L, Vincent A, Vilchez JJ, Bataller L (2011) Peripheral nerve hyperexcitability: a clinical and immunologic study of 38 patients. Neurology 76:172–178
Serratrice G, Serratrice J (2011) Continuous muscle activity, Morvan’s syndrome and limbic encephalitis: ionic or non ionic disorders? Acta Myol 30:32–33
Spillane J, Beeson DJ, Kullmann DM (2010) Myasthenia and related disorders of the neuromuscular junction. J Neurol Neurosurg Psychiatry 81:850–857
Zhang JC, Sun L, Nie QH (2010) Botulism, where are we now? Clin Toxicol 48:867–879
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Löscher, W.N. (2014). Neuromuscular Transmission: Endplate Disorders. In: Atlas of Neuromuscular Diseases. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1605-0_10
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