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The Intervertebral Disc pp 53–77Cite as

Proteoglycans of the Intervertebral Disc

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Abstract

Proteoglycans are present within the extracellular matrix (ECM) of the intervertebral disc and on the surface of its cells. The disc possesses many matrix proteoglycans, with most also being present in hyaline cartilages. The best studied of these are aggrecan and versican (members of the hyalectan/lectican family) and decorin, biglycan, fibromodulin, lumican, PRELP, and chondroadherin (members of the small leucine-rich repeat protein/SLRP family). More recently, the disc has also been shown to contain perlecan and lubricin, which were previously thought to be characteristic of basement membranes and the surface of articular cartilage, respectively. Much less is known about the disc cell-associated proteoglycans, though it is likely that several members of the syndecan (Tkachenko et al. 2005) and glypican (Fransson et al. 2004) families will be present, together with other unrelated proteoglycans such as NG2 (Akeda et al. 2007; Stallcup 2002). While little is known concerning the specific function of the cell-associated proteoglycans within the disc, it has been shown that syndecan-4 expression is increased when elevated levels of interleukin-1 (IL-1) or tumor necrosis factor-α (TNF-α) are present (Wang et al. 2011), and that it may play a role in promoting aggrecanase-mediated proteolysis within the disc. However, due to the scarcity of information on disc cell-associated proteoglycans, this chapter will focus on the matrix proteoglycans, in particular aggrecan.

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Acknowledgements

We would like to thank the Shriners of North America and the Canadian Institutes of Health Research for support of the work described in this chapter. Support from the National Health and Medical Research Council of Australia is also gratefully acknowledged.

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  1. Kolling Institute (B6), Level 10, Royal NorthShore Hospital, St. Leonards, New South Wales, 2065, Australia

    James Melrose

  2. Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, QC, Canada, H3G 1A6

    Peter Roughley

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Correspondence to James Melrose .

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  1. Jefferson Medical College Div Ortho Rsch/Dept Othro Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Irving M. Shapiro

  2. Jefferson Medical College Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Makarand V. Risbud

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Melrose, J., Roughley, P. (2014). Proteoglycans of the Intervertebral Disc. In: Shapiro, I., Risbud, M. (eds) The Intervertebral Disc. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1535-0_4

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