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Sphingolipids in Neuroinflammation

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Sphingolipids in Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 216))

Abstract

Sphingolipids, the main component of cellular membranes, are cellular ‘jack-of-all-trades’, influencing a variety of functions including signal transduction, cell activation, membrane fluidity and cell–cell interactions.

In the last few years, sphingolipids have begun to be investigated in the pathophysiology of major diseases of the brain, e.g. multiple sclerosis and dementia. Modulation of neuroinflammatory responses, such as lymphocyte behaviour, is a chance to intervene in the pathways that cause disease. There is much research still to be done in this field, but the prospect of treating previously untreatable medical conditions compels us onwards. Here, we review the current knowledge of the link between sphingolipids and neuroinflammation.

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Authors and Affiliations

  1. Department of Neurology, Saarland University Hospital, Kirrbergerstr, 66424, Homburg, Germany

    Laura Davies, Klaus Fassbender & Silke Walter

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  1. Laura Davies
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  2. Klaus Fassbender
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  3. Silke Walter
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Correspondence to Silke Walter .

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Editors and Affiliations

  1. , Department of Molecular Biology, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany

    Erich Gulbins

  2. Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, W. Walnut Street 980, Indianapolis, 46202, Indiana, USA

    Irina Petrache

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Davies, L., Fassbender, K., Walter, S. (2013). Sphingolipids in Neuroinflammation. In: Gulbins, E., Petrache, I. (eds) Sphingolipids in Disease. Handbook of Experimental Pharmacology, vol 216. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1511-4_21

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