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Stereotactic and Functional Neurosurgery pp 87–92Cite as

Some Recent Trends and Further Promising Directions in Functional Neurosurgery

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 117))

Abstract

The field of functional neurosurgery has developed a number of recent innovative neuromodulatory approaches to treat disease that remains resistant to the best medical therapy. These include novel surgical techniques to intervene in motor and cognitive sequelae of refractory epilepsy, neurodegenerative disease, and certain psychiatric conditions. To a large extent, much of the innovation in our field continues to be driven by a systems-level understanding of the impact of disease on the brain. For example, several groups have exploited findings from neuroimaging work to identify a number of new potential neuromodulatory targets for the treatment of refractory depression. Ongoing discoveries at the cellular and molecular level promise targeted gene or drug delivery aimed at curing disease. Neurosurgeons will certainly remain at the forefront of translating these strategies into practical clinical applications. Several randomized trials are now underway to assess the safety and efficacy of a number of new approaches, and we will continue to acquire better knowledge of optimal patient selection, identification of the most effective neuromodulatory targets, and recognition of adverse effects as these studies progress.

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Conflict of Interest

TST and TS declare that they have no conflict of interest. AML holds intellectual property rights in the field of deep brain stimulation, and has served as a consultant for Medtronic and St. Jude corporations.

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Authors and Affiliations

  1. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Travis S. Tierney MD, PhD

  2. Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada

    Tejas Sankar MDCM & Andres M. Lozano MD, PhD, FRCSC, FRS

  3. Department of Neurosurgery, University of Toronto, Toronto Western Hospital, 399 Bathurst Street, WW 4-431, Toronto, ON, M5T 2S8, Canada

    Andres M. Lozano MD, PhD, FRCSC, FRS

Authors
  1. Travis S. Tierney MD, PhD
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  2. Tejas Sankar MDCM
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  3. Andres M. Lozano MD, PhD, FRCSC, FRS
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Corresponding author

Correspondence to Andres M. Lozano MD, PhD, FRCSC, FRS .

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Editors and Affiliations

  1. , Neurosurgical Clinic, University Hospital Erlangen, Schwabachanlage 6, Erlangen, 91054, Germany

    Guido Nikkhah

  2. Department of Neurosurgery, Division of Stereotactic and Functional, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, 79106, Germany

    Marcus Pinsker

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Tierney, T.S., Sankar, T., Lozano, A.M. (2013). Some Recent Trends and Further Promising Directions in Functional Neurosurgery. In: Nikkhah, G., Pinsker, M. (eds) Stereotactic and Functional Neurosurgery. Acta Neurochirurgica Supplement, vol 117. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1482-7_14

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