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PET Molecular Imaging to Investigate Higher Brain Dysfunction in Patients with Neurotrauma

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Brain Edema XV

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 118))

Abstract

Introduction: Many neurotrauma patients suffer from higher brain dysfunction even when focal brain damage is not detected with MRI. We performed functional imaging with positron emission tomography (PET) to clarify the relationship between the functional deficit and symptoms of such patients. Methods: Patients who complain of higher brain dysfunction without apparent morphological cortical damage were recruited. Thirteen patients underwent PET study to image glucose metabolism by 18F-FDG, and central benzodiazepine receptor (cBZD-R) by 11C-flumazenil, together with measurement of cognition. Results: Diffuse axonal injury (DAI) patients have a significant decrease in glucose metabolism and cBZD-R distribution in the cingulated cortex than normal controls. Score of cognition test was variable among patients. The degree of decreased glucose metabolism and cBZD-R in the dominant hemisphere corresponded well to the severity of cognitive disturbance. Patients with a milder type of diffuse brain injury (i.e., cerebral concussion) also showed abnormal glucose metabolism and cBZD-R distribution when they suffered from cognitive deficit. Conclusion: PET molecular imaging was useful for depicting the cortical dysfunction of neurotrauma patients even when morphological change was not apparent. This method may be promising in clarifying the pathophysiology of higher brain dysfunction of patients with neurotrauma, but without morphological abnormality.

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Acknowledgment

This study was supported by a research grant from The General Insurance Association of Japan.

Conflict of InterestWe declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

    Tadashi Nariai, Motoki Inaji, Yoji Tanaka & Kikuo Ohno

  2. Faculty of Sports and Health Science, Hosei University, Tokyo, Japan

    Mikio Hiura

  3. Department of Cortical Function Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

    Chihiro Hosoda

  4. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan

    Kenji Ishii

Authors
  1. Tadashi Nariai
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  2. Motoki Inaji
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  3. Yoji Tanaka
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  4. Mikio Hiura
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  5. Chihiro Hosoda
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  6. Kenji Ishii
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  7. Kikuo Ohno
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Corresponding author

Correspondence to Tadashi Nariai .

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Editors and Affiliations

  1. School of Medicine, Dept. Neurological Surgery, Nihon University, Oyaguchikami-machi 30-1, Tokyo, 173-8610, Japan

    Yoichi Katayama

  2. School of Medicine, Departments of Neurological Surgery and, Nihon University, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan

    Takeshi Maeda

  3. , Department of Clinical Laboratory, Namegata District General Hospital, 98-8 Inouefujii, Namegata 98-8, Ibaraki, 311-3516, Japan

    Toshihiko Kuroiwa

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Nariai, T. et al. (2013). PET Molecular Imaging to Investigate Higher Brain Dysfunction in Patients with Neurotrauma. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_47

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  • DOI: https://doi.org/10.1007/978-3-7091-1434-6_47

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1433-9

  • Online ISBN: 978-3-7091-1434-6

  • eBook Packages: MedicineMedicine (R0)

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