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Brain Edema XV pp 99–101Cite as

A Better Mild Traumatic Brain Injury Model in the Rat

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 118))

Abstract

The primary pathology associated with mild ­traumatic brain injury (TBI) is selective axonal injury, which may characterize the vast majority of blast-induced TBIs. Axonal injuries in cases of mild TBI have been considered to be the main factors responsible for the long-lasting memory or attentional impairment in affected subjects. Among these axonal injuries, recent attention has been focused on the cingulum bundle (CB). Furthermore, recent studies with diffusion tensor MR imaging have shown the presence of injuries of the CB in cases of mild TBI in humans. This study aimed to provide a better laboratory model of mild TBI.

Sprague–Dawley rats were subjected to mild TBI using laser-induced shock waves (LISW) (sham, 0.5 J/cm2, or 1.0 J/cm2; n = 4 per group). Bodian-stained brain sections 14 days after LISW at 0.5 J/cm2 or 1.0 J/cm2 showed a decrease in the CB axonal density compared with the sham group, whereas there were no differences in the axonal density of the corpus callosum.

The present study shows that this model is capable of reproducing the histological changes associated with mild TBI.

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References

  1. Cheng J, Gu J, Ma Y, Yang T, Kuang Y, Li B, Kang J (2010) Development of a rat model for studying blast-induced traumatic brain injury. J Neurol Sci 294:23–28

    Article  PubMed  Google Scholar 

  2. Desmoulin GT, Dionne JP (2009) Blast-induced neurotrauma: surrogate use, loading mechanisms, and cellular responses. J Trauma 67:1113–1122

    Article  PubMed  Google Scholar 

  3. Hatano B, Matsumoto Y, Otani N, Saitoh D, Tokuno S, Satoh Y, Nawashiro H, Matsushita Y, Sato S (2011) Traumatic brain injury caused by laser-induced shock wave in rats: a novel laboratory model for studying blast-induced traumatic brain injury. Proc SPIE 7897:78971V. doi:10.1117/12.875909

    Article  Google Scholar 

  4. Hicks RR, Fertig SJ, Desrocher RE, Koroshetz WJ, Pancrazio JJ (2010) Neurological effects of blast injury. J Trauma 68:1257–1263

    Article  PubMed  Google Scholar 

  5. Kocsis JD, Tessler A (2009) Pathology of blast-related brain injury. J Rehabil Res Dev 46:667–672

    Article  PubMed  Google Scholar 

  6. Koliatsos VE, Cernak I, Xu L, Song Y, Savonenko A, Crain BJ, Eberhart CG, Frangakis CE, Melnikova T, Kim H, Lee D (2011) A mouse model of blast injury to brain: initial pathological, ­neuropathological, and behavioral characterization. J Neuropathol Exp Neurol 70:399–416

    Article  PubMed  Google Scholar 

  7. Long JB, Bentley TL, Wessner KA, Cerone C, Sweeney S, Bauman RA (2009) Blast overpressure in rats: recreating a battlefield injury in the laboratory. J Neurotrauma 26:827–840

    Article  PubMed  Google Scholar 

  8. Mac Donald CL, Johnson AM, Cooper D, Nelson EC, Werner NJ, Shimony JS, Snyder AZ, Raichle ME, Witherow JR, Fang R, Flaherty SF, Brody DL (2011) Detection of blast-related traumatic brain injury in U.S. military personnel. N Engl J Med 364:2091–2100

    Article  PubMed  CAS  Google Scholar 

  9. Matsumoto Y, Hatano B, Matsushita Y, Nawashiro H, Shima K (2010) The characteristics of blast traumatic brain injury. No Shinkei Geka 38:695–702

    PubMed  Google Scholar 

  10. Neave N, Nagle S, Aggleton JP (1997) Evidence for the involvement of the mammillary bodies and cingulum bundle in allocentric spatial processing by rats. Eur J Neurosci 9:941–955

    Article  PubMed  CAS  Google Scholar 

  11. Satoh Y, Sato S, Saitoh D, Tokuno S, Hatano B, Shimokawaji T, Kobayashi H, Takishima K (2010) Pulmonary blast injury in mice: a novel model for studying blast injury in the laboratory using laser-induced stress waves. Lasers Surg Med 42:313–318

    Article  PubMed  Google Scholar 

  12. Svetlov SI, Prima V, Kirk DR, Gutierrez H, Curley KC, Hayes RL, Wang KK (2010) Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. J Trauma 69:795–804

    Article  PubMed  CAS  Google Scholar 

  13. Takeuchi S, Nawashiro H (2011) Atrophy after traumatic axonal injury. Arch Neurol 68:1090

    Article  PubMed  Google Scholar 

  14. Walilko T, North C, Young LA, Lux WE, Warden DL, Jaffee MS, Moore DF (2009) Head injury as a PTSD predictor among Oklahoma City bombing survivors. J Trauma 67:1311–1319

    Article  PubMed  Google Scholar 

  15. Wu TC, Wilde EA, Bigler ED, Yallampalli R, McCauley SR, Troyanskaya M, Chu Z, Li X, Hanten G, Hunter JV, Levin HS (2010) Evaluating the relationship between memory functioning and cingulum bundles in acute mild traumatic brain injury using diffusion tensor imaging. J Neurotrauma 27:303–307

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was supported by a research grant from The General Insurance Association of Japan.

Conflict of InterestWe declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Satoru Takeuchi, Hiroshi Nawashiro, Kimihiro Nagatani, Hiroaki Kobayashi, Naoki Otani, Hideo Osada, Kojiro Wada & Katsuji Shima

  2. Division of Biomedical Information Sciences, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Shunichi Sato & Satoko Kawauchi

Authors
  1. Satoru Takeuchi
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  2. Hiroshi Nawashiro
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  3. Shunichi Sato
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  4. Satoko Kawauchi
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  5. Kimihiro Nagatani
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  6. Hiroaki Kobayashi
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  7. Naoki Otani
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  8. Hideo Osada
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  9. Kojiro Wada
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  10. Katsuji Shima
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Corresponding author

Correspondence to Satoru Takeuchi .

Editor information

Editors and Affiliations

  1. School of Medicine, Dept. Neurological Surgery, Nihon University, Oyaguchikami-machi 30-1, Tokyo, 173-8610, Japan

    Yoichi Katayama

  2. School of Medicine, Departments of Neurological Surgery and, Nihon University, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan

    Takeshi Maeda

  3. , Department of Clinical Laboratory, Namegata District General Hospital, 98-8 Inouefujii, Namegata 98-8, Ibaraki, 311-3516, Japan

    Toshihiko Kuroiwa

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© 2013 Springer-Verlag Wien

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Takeuchi, S. et al. (2013). A Better Mild Traumatic Brain Injury Model in the Rat. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_17

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  • DOI: https://doi.org/10.1007/978-3-7091-1434-6_17

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1433-9

  • Online ISBN: 978-3-7091-1434-6

  • eBook Packages: MedicineMedicine (R0)

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