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Models to Study Glioma Cell Invasion

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Glioma Cell Biology

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Abstract

Gliomas represent the most common primary intracranial tumors. The aggressive clinical behavior of these tumors stems from the highly invasive properties of neoplastic glial cells. Fundamental to the development of an effective clinical treatment is the need to therapeutically target this invasive potential. Research into the mechanisms of invasion is imperative to better understand the various biological processes that could be targeted to treat the invading glioma cells. Such research is ideally conducted with reliable and relevant models. We describe some of the most commonly used models in glioma invasion research. Each model has its benefits and drawbacks and the nature of the experiments being conducted will help choose the type of model most suitable.

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Abbreviations

ADAM:

A disintegrin and metalloproteinase

ECM:

Extracellular matrix

EGFP:

Enhanced green fluorescent protein

EGFR:

Epidermal growth factor receptor

ENU:

N-Ethyl-N nitrosourea

GBM:

Glioblastoma multiforme

GFAP:

Glial fibrillary acidic protein

MCS:

Multicellular spheroid

MMP:

Matrix metalloproteinase

MNU:

Methynitrosourea

MRI:

Magnetic resonance imaging

PDGF:

Platelet-derived growth factor

PTEN:

Phosphatase and tensin homolog deleted from chromosome 10

Rb:

Retinoblastoma protein

RFP:

Red fluorescent protein

VEGF:

Vascular endothelial cell growth factor

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  1. Department of Neurosurgery, Vanderbilt University Medical Center, T-4224 Medical Center North, 1161 21st Ave S, Nashville, TN, 37201, USA

    Imad Saeed Khan & Moneeb Ehtesham

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Correspondence to Moneeb Ehtesham .

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  1. Biochemistry and Experimental Oncology, Charles University Prague 1st Faculty of Medicine, Prague, Czech Republic

    Aleksi Sedo

  2. Anatomisches Institut, Christian-Albrechts-Universität zu Kiel, Kiel, Germany

    Rolf Mentlein

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Khan, I.S., Ehtesham, M. (2014). Models to Study Glioma Cell Invasion. In: Sedo, A., Mentlein, R. (eds) Glioma Cell Biology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1431-5_14

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