Abstract
In many parts of the world, microbial diseases have been controlled by a combination of improved hygiene practices, surveillance, diagnosis, treatments, effective vaccines, as well as greater public education and awareness of risk factors. Control strategies are especially challenging for diseases caused by pathogens that persist in a mammalian wildlife reservoir and use vectors such as insects to cycle through that species. In this group, the most relevant illnesses that pose a direct human health risk are rabies, sylvatic plague, and Lyme disease [1].
Reservoir-targeted vaccines have been developed as vaccination strategies that target the host reservoir or the transmitting vector both for rabies and for Lyme disease. An example of a successful application is the oral vaccine (RaboralTM) currently used by local governments in the United States to create barriers between infected wildlife and highly populated areas to prevent transmission of rabies.
In this chapter I will discuss the development of an oral reservoir-targeted vaccine to curb transmission of Borrelia burgdorferi within wildlife and its projected impact on reduction of the incidence of Lyme disease in humans.
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References
Cross, M.L., Buddle, B.M., Aldwell, F.E.: The potential of oral vaccines for disease control in wildlife species. Vet. J. 174, 472–480 (2007). doi:10.1016/j.tvjl.2006.10.005
Radolf, J.D., Caimano, M.J., Stevenson, B., Hu, L.T.: Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat. Rev. Microbiol. 10, 87–99 (2012). doi:10.1038/nrmicro2714
Stanek, G., Wormser, G.P., Gray, J., Strle, F.: Lyme borreliosis. Lancet 379, 461–473 (2012). doi:10.1016/S0140-6736(11)60103-7
Kurtenbach, K., et al.: Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nat. Rev. Microbiol. 4, 660–669 (2006). doi:10.1038/nrmicro1475
O’Connell, S., Granstrom, M., Gray, J.S., Stanek, G.: Epidemiology of European Lyme borreliosis. Zentralbl. Bakteriol. 287, 229–240 (1998)
Ribeiro, J.M., Mather, T.N., Piesman, J., Spielman, A.: Dissemination and salivary delivery of Lyme disease spirochetes in vector ticks (Acari: Ixodidae). J. Med. Entomol. 24, 201–205 (1987)
Piesman, J., Mather, T.N., Sinsky, R.J., Spielman, A.: Duration of tick attachment and Borrelia burgdorferi transmission. J. Clin. Microbiol. 25, 557–558 (1987)
Fraser, C.M., et al.: Genomic sequence of a Lyme disease spirochaete Borrelia burgdorferi. Nature 390, 580–586 (1997). doi:10.1038/37551
Weis, J.J., Bockenstedt, L.K.: In: Samuels, D.S., Radolf, J.D. (eds.) Lyme Disease in Humans. Borrelia: Molecular Biology, Host Interaction, and Pathogenesis, pp. 413–441. Caister Academic, Norfolk (2010)
Cerar, D., Cerar, T., Ruzic-Sabljic, E., Wormser, G.P., Strle, F.: Subjective symptoms after treatment of early Lyme disease. Am. J. Med. 123, 79–86 (2010). doi:10.1016/j.amjmed.2009.05.011
Radolf, J.D., Salazar, J.C., Dattwyler, R.J.: Lyme Disease in Humans. In: Samuels, D.S., Radolf, J.D. (eds.) Borrelia: Molecular Biology, Host Interaction, and Pathogenesis, pp. 487–533. Caister Academic, Norfolk (2010)
Bacon, R.M., Kugeler, K.J., Mead, P.S.: Surveillance for Lyme disease–United States, 1992–2006. MMWR Surveill. Summ. 57, 1–9 (2008)
Wormser, G.P., et al.: Brief communication: hematogenous dissemination in early Lyme disease. Ann. Intern. Med. 142, 751–755 (2005)
Stanek, G., Strle, F.: Lyme disease: European perspective. Infect. Dis. Clin. North Am. 22, 327–339, vii (2008). doi:10.1016/j.idc.2008.01.001
Wormser, G.P., et al.: The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis. 43, 1089–1134 (2006). doi:10.1086/508667
Stanek, G., et al.: Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin. Microbiol. Infect. 17, 69–79 (2011). doi:10.1111/j.1469-0691.2010.03175.x
Halperin, J.J.: Nervous system Lyme disease. Infect. Dis. Clin. North Am. 22, 261–274, vi (2008). doi:10.1016/j.idc.2007.12.009(2008)
Rizzoli, A. et al.: Lyme borreliosis in Europe. Euro Surveill. 16(27) (2011) p. 8, pii: 19906
Dennis, D.T., Hayes, E.B.: Epidemiology of lyme borreliosis. In: Gray, J.S., Kahl, O., Lane, R.S., Stanek, G. (eds.) Lyme Borreliosis: Biology, Epidemiology and Control, 1st edn, pp. 251–280. Cabi Publishing, New York (2002)
Gray, J.S., Kahl, O., Janetzki, C., Stein, J., Guy, E.: The spatial distribution of Borrelia burgdorferi-infected Ixodes ricinus in the Connemara region of county Galway Ireland. Exp. Appl. Acarol. 19, 163– 172 (1995)
des Vignes, F., et al.: Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs. J. Infect. Dis. 183, 773–778 (2001). doi:10.1086/318818
Peavey, C.A., Lane, R.S.: Transmission of Borrelia burgdorferi by Ixodes pacificus nymphs and reservoir competence of deer mice (Peromyscus maniculatus) infected by tick-bite. J. Parasitol. 81, 175–178 (1995)
Einsen, L., Lane, R.S.: Vectors of Borrelia burgdorferi sensu lato. In: Gray, J.S., Kahl, O., Lane, R.S., Stanek, G. (eds.) Lyme Borreliosis: Biology, Epidemiology and Control, 1st edn, pp. 91–115. Cabi Publishing, New York (2002)
Kahl, O., et al.: Risk of infection with Borrelia burgdorferi sensu lato for a host in relation to the duration of nymphal Ixodes ricinus feeding and the method of tick removal. Zentralbl Bakteriol 287, 41–52 (1998)
Ogden, N.H., Nuttall, P.A., Randolph, S.E.: Natural Lyme disease cycles maintained via sheep by co-feeding ticks. Parasitology 115(Pt 6), 591–599 (1997)
Matuschka, F.R., et al.: Diversionary role of hoofed game in the transmission of Lyme disease spirochetes. Am. J. Trop. Med. Hyg. 48, 693–699 (1993)
Bykowski, T., et al.: Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): expression patterns during the mammal-tick infection cycle. Int. J. Med. Microbiol. 298(Suppl 1), 249–256 (2008). doi:10.1016/j.ijmm.2007.10.002
EUCALB: European Union Concerted Action on Lyme Borreliosis. An information resource of the ESCMID study group, ESGBOR. Accessed Aug 22, 2013. www.eucalb.com
Brisson, D., Dykhuizen, D.E.: OspC diversity in Borrelia burgdorferi: different hosts are different niches. Genetics 168, 713–722 (2004). doi:10.1534/genetics.104.028738
LoGiudice, K., Ostfeld, R.S., Schmidt, K.A., Keesing, F.: The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk. Proc. Natl. Acad. Sci. U.S.A. 100, 567–571 (2003). doi:10.1073/pnas.0233733100
De Boer, R., Hovius, K.E., Nohlmans, M.K., Gray, J.S.: The woodmouse (Apodemus sylvaticus) as a reservoir of tick-transmitted spirochetes (Borrelia burgdorferi) in the Netherlands. Zentralbl. Bakteriol. 279, 404–416 (1993)
Dykhuizen, D.E., et al.: The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans. Am. J. Trop. Med. Hyg. 78, 806–810 (2008)
Mannelli, A., Bertolotti, L., Gern, L., Gray, J.: Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi-host systems, influence of molecular processes and effects of climate change. FEMS Microbiol. Rev. 36, 837–861 (2012). doi:10.1111/j.1574-6976.2011.00312.x
Dsouli, N., et al.: Reservoir role of lizard Psammodromus algirus in transmission cycle of Borrelia burgdorferi sensu lato (Spirochaetaceae) in Tunisia. J. Med. Entomol. 43, 737–742 (2006)
Gray, J.S., Kahl, O., Janetzki, C., Stein, J.: Studies on the ecology of Lyme disease in a deer forest in county Galway Ireland. J. Med. Entomol. 29, 915–920 (1992)
Kimura, K., et al.: Prevalence of antibodies against Borrelia species in patients with unclassified uveitis in regions in which Lyme disease is endemic and nonendemic. Clin. Diagn. Lab. Immunol. 2, 53–56 (1995)
Pichon, B., Rogers, M., Egan, D., Gray, J.: Blood-meal analysis for the identification of reservoir hosts of tick-borne pathogens in Ireland. Vector Borne Zoonotic Dis. 5, 172–180 (2005). doi:10.1089/vbz.2005.5.172
Jaenson, T.G., Talleklint, L.: Lyme borreliosis spirochetes in Ixodes ricinus (Acari:Ixodidae) and the varying hare on isolated islands in the Baltic Sea. J. Med. Entomol. 33, 339–343 (1996)
Gern, L., Rouvinez, E., Toutoungi, L.N., Godfroid, E.: Transmission cycles of Borrelia burgdorferi sensu lato involving Ixodes ricinus and/or I. Hexagonus ticks and the European hedgehog, Erinaceus europaeus, in suburban and urban areas in Switzerland. Folia Parasitol. 44, 309–314 (1997)
Wormser, G.P., et al.: Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease. J. Infect. Dis. 198, 1358–1364 (2008). doi:10.1086/592279
Fish, A.E., Pride, Y.B., Pinto, D.S.: Lyme carditis. Infect. Dis. Clin. North Am. 22, 275–288, vi (2008). doi:10.1016/j.idc.2007.12.008
Marques, A.: Chronic Lyme disease: a review. Infect. Dis. Clin. North Am. 22, 341–360, vii-viii (2008). doi:10.1016/j.idc.2007.12.011
Cerar, T., et al.: Validation of cultivation and PCR methods for diagnosis of Lyme neuroborreliosis. J. Clin. Microbiol. 46, 3375–3379 (2008). doi:10.1128/JCM.00410-08
Aguero-Rosenfeld, M.E., Wang, G., Schwartz, I., Wormser, G.P.: Diagnosis of lyme borreliosis. Clin. Microbiol. Rev. 18, 484–509 (2005). doi:10.1128/CMR.18.3.484-509.2005
Wilske, B., Fingerle, V., Schulte-Spechtel, U.: Microbiological and serological diagnosis of Lyme borreliosis. FEMS Immunol. Med. Microbiol. 49, 13–21 (2007). doi:10.1111/j.1574-695X.2006.00139.x
CDC. Lyme disease diagnosis and treatment. http://www.cdc.gov/lyme/diagnosistreatment/index.html (2012)
Hunfeld, K.P., Ruzic-Sabljic, E., Norris, D.E., Kraiczy, P., Strle, F.: In vitro susceptibility testing of Borrelia burgdorferi sensu lato isolates cultured from patients with erythema migrans before and after antimicrobial chemotherapy. Antimicrob. Agents Chemother. 49, 1294–1301 (2005). doi:10.1128/AAC.49.4.1294-1301.2005
Morgenstern, K., et al.: In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. Antimicrob. Agents Chemother. 53, 1281–1284 (2009). doi:10.1128/AAC.01247-08
Stafford, K.I., Kitron, U.: Environmental management of Lyme borreliosis control. In: Gray, J.S., Kahl, O., Lane, R.S., Stanek, G. (eds.) Lyme Borreliosis: Biology, Epidemiology and Control, pp. 301–334. CABI Publishing, New York (2002)
Connally, N.P., et al.: Peridomestic Lyme disease prevention: results of a population-based case-control study. Am. J. Prev. Med. 37, 201–206 (2009). doi:10.1016/j.amepre.2009.04.026
Warshafsky, S., et al.: Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an updated systematic review and meta-analysis. J. Antimicrob. Chemother. 65, 1137–1144 (2010). doi:10.1093/jac/dkq097
Piesman, J.: Lyme borreliosis in North America. In: Gray, J.S., Kahl, O., Lane, R.S., Stanek, G. (eds.) Lyme Borreliosis: Biology, Epidemiology and Control, pp. 223–249. CABI Publishing, New York (2002)
Gern, L., Humair, P.F.: Lyme borreliosis in Europe. In: Gray, J.S., Kahl, O., Lane, R.S., Stanek, G. (eds.) Lyme Borreliosis: Biology, Epidemiology and Control, pp. 149–174. CABI Publishing, New York (2002)
Korenberg, E.I., Horakova, M., Kovalevsky, J.V., Hubalek, Z., Karavanov, A.S.: Probability models of the rate of infection with tick-borne encephalitis virus in Ixodes persulcatus ticks. Folia Parasitol. 39, 85–92 (1992)
Clark, R.P., Hu, L.T.: Prevention of Lyme disease and other tick-borne infections. Infect. Dis. Clin. North Am. 22, 381–396, vii (2008). doi:10.1016/j.idc.2008.03.007
Anderson, J.F., Johnson, R.C., Magnarelli, L.A.: Seasonal prevalence of Borrelia burgdorferi in natural populations of white-footed mice, Peromyscus leucopus. J. Clin. Microbiol. 25, 1564–1566 (1987)
Anderson, J.F.: Ecology of Lyme disease. Conn. Med. 53, 343–346 (1989)
Comstedt, P., et al.: Migratory passerine birds as reservoirs of Lyme borreliosis in Europe. Emerg. Infect. Dis. 12, 1087–1095 (2006)
Tsao, J.I., et al.: An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc. Natl. Acad. Sci. U.S.A. 101, 18159–18164 (2004). doi:10.1073/pnas.0405763102
Gomes-Solecki, M.J., Brisson, D.R., Dattwyler, R.J.: Oral vaccine that breaks the transmission cycle of the Lyme disease spirochete can be delivered via bait. Vaccine 24, 4440–4449 (2006). doi:10.1016/j.vaccine.2005.08.089
Scheckelhoff, M.R., Telford, S.R., Hu, L.T.: Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs. Vaccine 24, 1949–1957 (2006). doi:10.1016/j.vaccine.2005.10.044
Piesman, J.: Strategies for reducing the risk of Lyme borreliosis in North America. Int. J. Med. Microbiol. 296(Suppl 40), 17–22 (2006). doi:10.1016/j.ijmm.2005.11.007
Pastoret, P.P., et al.: First field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus. Vet. Rec. 123, 481–483 (1988)
Estrada, R., Vos, A., De Leon, R., Mueller, T.: Field trial with oral vaccination of dogs against rabies in the Philippines. BMC Infect. Dis. 1, 23 (2001)
Knobel, D.L., du Toit, J.T., Bingham, J.: Development of a bait and baiting system for delivery of oral rabies vaccine to free-ranging African wild dogs (Lycaon pictus). J. Wildl. Dis. 38, 352–362 (2002)
Creekmore, T.E., Rocke, T.E., Hurley, J.: A baiting system for delivery of an oral plague vaccine to black-tailed prairie dogs. J. Wildl. Dis. 38, 32–39 (2002)
Daniels, T.J., et al.: Acaricidal treatment of white-tailed deer to control Ixodes scapularis (Acari: Ixodidae) in a New York Lyme disease-endemic community. Vector Borne Zoonotic Dis. 9, 381–387 (2009). doi:10.1089/vbz.2008.0197
Fish, D., Childs, J.E.: Community-based prevention of Lyme disease and other tick-borne diseases through topical application of acaricide to white-tailed deer: background and rationale. Vector Borne Zoonotic Dis. 9, 357–364 (2009). doi:10.1089/vbz.2009.0022
Hoen, A.G., et al.: Effects of tick control by acaricide self-treatment of white-tailed deer on host-seeking tick infection prevalence and entomologic risk for Ixodes scapularis-borne pathogens. Vector Borne Zoonotic Dis. 9, 431–438 (2009). doi:10.1089/vbz.2008.0155
Stafford 3rd, K.C., Denicola, A.J., Pound, J.M., Miller, J.A., George, J.E.: Topical treatment of white-tailed deer with an acaricide for the control of Ixodes scapularis (Acari: Ixodidae) in a Connecticut Lyme borreliosis hyperendemic community. Vector Borne Zoonotic Dis. 9, 371–379 (2009). doi:10.1089/vbz.2008.0161
Dolan, M.C., et al.: Control of immature Ixodes scapularis (Acari: Ixodidae) on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. J. Med. Entomol. 41, 1043–1054 (2004)
Dolan, M.C., et al.: A doxycycline hyclate rodent bait formulation for prophylaxis and treatment of tick-transmitted Borrelia burgdorferi. Am. J. Trop. Med. Hyg. 78, 803–805 (2008)
Zeidner, N.S., et al.: A sustained-release formulation of doxycycline hyclate (Atridox) prevents simultaneous infection of Anaplasma phagocytophilum and Borrelia burgdorferi transmitted by tick bite. J. Med. Microbiol. 57, 463–468 (2008). doi:10.1099/jmm.0.47535-0
Oliver Jr., J.H., et al.: An enzootic transmission cycle of Lyme borreliosis spirochetes in the southeastern United States. Proc. Natl. Acad. Sci. U.S.A. 100, 11642–11645 (2003). doi:10.1073/pnas.1434553100
Embers ME., Hasenkampf NR., Jacobs MB., Philipp MT.: Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques. Clin Vaccine Immunol. 19(8), 1218–1226 (2012). doi: 10.1128/CVI.00228-12. Epub 2012 Jun 20. PMID: 22718128
Meirelles Richer, L., Aroso, M., Contente-Cuomo, T., Ivanova, L., Gomes-Solecki, M.: Reservoir targeted vaccine for lyme borreliosis induces a yearlong, neutralizing antibody response to OspA in white-footed mice. Clin. Vaccine Immunol. 18, 1809–1816 (2011). doi: 10.1128/CVI.05226-11
Fikrig, E., Barthold, S.W., Kantor, F.S., Flavell, R.A.: Long-term protection of mice from Lyme disease by vaccination with OspA. Infect. Immun. 60, 773–777 (1992)
de Silva, A.M., Telford 3rd, S.R., Brunet, L.R., Barthold, S.W., Fikrig, E.: Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J. Exp. Med. 183, 271–275 (1996)
Steere, A.C., et al.: Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein a with adjuvant. Lyme Disease Vaccine Study Group. N. Engl. J. Med. 339, 209–215 (1998). doi:10.1056/NEJM199807233390401
Alexopoulou, L., et al.: Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat. Med. 8, 878–884 (2002). doi:10.1038/nm732
Schuijt, T.J., Hovius, J.W., van der Poll, T., van Dam, A.P., Fikrig, E.: Lyme borreliosis vaccination: the facts, the challenge, the future. Trends Parasitol. 27, 40–47 (2011). doi:10.1016/j.pt.2010.06.006
Bhattacharya, D., et al.: Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease. Vaccine 29, 7818–7825 (2011). doi:10.1016/j.vaccine.2011.07.100
Reed, J.L., Scott, D.E., Bray, M.: Eczema vaccinatum. Clin. Infect. Dis. 54, 832–840 (2012). doi:10.1093/cid/cir952
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Gomes-Solecki, M. (2013). Lyme Disease: Reservoir-Targeted Vaccines. In: Giese, M. (eds) Molecular Vaccines. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1419-3_16
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