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Regulation of Cardiac Hypertrophy by T-Type Ca2+ Channel

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T-type Calcium Channels in Basic and Clinical Science

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Abstract

Congestive heart failure is a terminal condition whose progression is determined by both cardiomyocyte and ventricular remodeling. Among the pathways contributing to remodeling are the calcium-dependent calcineurin–NFAT and CREB hypertrophic pathways. While the T-type Ca2+ channel and the transient receptor potential anion channel superfamily assume central roles in initiation of cardiac hypertrophy involving the calcineurin–NFAT pathway, the T-type Ca2+ channel appears to regulate the calcineurin–NFAT hypertrophic pathway. The T-type Ca2+ channel also modulates the development of pathological hypertrophy via the CREB hypertrophic pathway.

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  1. Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA

    Stephen W. Schaffer & Chian Ju Jong

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  1. Stephen W. Schaffer
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  2. Chian Ju Jong
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Correspondence to Stephen W. Schaffer .

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  1. Dept. Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen W. Schaffer

  2. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Ming Li

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Schaffer, S.W., Jong, C.J. (2015). Regulation of Cardiac Hypertrophy by T-Type Ca2+ Channel. In: Schaffer, S., Li, M. (eds) T-type Calcium Channels in Basic and Clinical Science. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1413-1_5

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