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Role of T-Type Calcium Channels in Neuroendocrine Differentiation

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T-type Calcium Channels in Basic and Clinical Science

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Abstract

Neuroendocrine cells release their secretory products into the extracellular environment via a calcium-dependent pathway. These particular cells share common morphological and molecular features, such as the expression of specific biomarkers, neurite outgrowth and dense-core secretory granules. In order to elucidate the signalling pathways leading from undifferentiated to differentiated neuroendocrine cells, the role of voltage-dependent calcium channels and central actors in excitation–secretion coupling has been comprehensively investigated. T-type calcium channels, comprising of three different molecular isoforms, appear to be one of the important calcium channel families involved in the neuroendocrine differentiation process. They also may participate in the development of neuroendocrine tumours.

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Authors and Affiliations

  1. Laboratoire de Physiologie Cellulaire, Inserm U1003, Université des Sciences et Technologies de Lille 1, 59650, Villeneuve d’Ascq, France

    Marine Warnier, Florian Gackière, Morad Roudbaraki & Pascal Mariot

  2. Laboratory of Excellence, Ion Channels Science and Therapeutics, Université des Sciences et Technologies de Lille 1, 59650, Villeneuve d’Ascq, France

    Marine Warnier, Florian Gackière, Morad Roudbaraki & Pascal Mariot

Authors
  1. Marine Warnier
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  2. Florian Gackière
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  3. Morad Roudbaraki
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  4. Pascal Mariot
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Correspondence to Marine Warnier .

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Editors and Affiliations

  1. Dept. Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen W. Schaffer

  2. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Ming Li

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Warnier, M., Gackière, F., Roudbaraki, M., Mariot, P. (2015). Role of T-Type Calcium Channels in Neuroendocrine Differentiation. In: Schaffer, S., Li, M. (eds) T-type Calcium Channels in Basic and Clinical Science. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1413-1_4

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