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Regulation of T-Type Ca2+ Channels by Intercellular and Intracellular Signals

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Book cover T-type Calcium Channels in Basic and Clinical Science

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Abstract

T-type Ca2+ channels play many important physiological functions in different tissues; this makes the channels targets for extracellular and intracellular regulation. T-type Ca2+ channels in many non-excitable cells provide an essential mechanism for Ca2+ entry at voltages near the resting membrane potential, which revises the homeostasis of the intracellular Ca2+ concentration to promote cell cycling and cell duplication. Consistent with this function, many of the extracellular signals stimulate the expression of T-type Ca2+ channels. The intracellular signaling pathways regulating the T-type Ca2+ channels are frequently observed in excitable cells. In these cases, the role of T-type Ca2+ current is to modify threshold and the shape of repetitive firing of action potentials. Therefore, intracellular signaling pathways can either up- or downregulate T-type Ca2+ channels. The regulation of the α1H isoform of the T-type Ca2+ channels is frequently located on the intracellular loop between domains II and III.

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Authors and Affiliations

  1. Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA, 70112, USA

    Ming Li

  2. Department of Anesthesiology and Perioperative Medicine, Georgia Regents University, Augusta, GA, 30912, USA

    Songwei Wu

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  1. Dept. Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen W. Schaffer

  2. Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Ming Li

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Li, M., Wu, S. (2015). Regulation of T-Type Ca2+ Channels by Intercellular and Intracellular Signals. In: Schaffer, S., Li, M. (eds) T-type Calcium Channels in Basic and Clinical Science. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1413-1_2

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