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Sphingolipids and Membrane Domains: Recent Advances

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Sphingolipids: Basic Science and Drug Development

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 215))

Abstract

There is growing evidence that cell membranes can contain domains with different lipid and protein compositions and with different physical properties. Furthermore, it is increasingly appreciated that sphingolipids play a crucial role in the formation and properties of ordered lipid domains (rafts) in cell membranes. This review describes recent advances in our understanding of ordered membrane domains in both cells and model membranes. In addition, how the structure of sphingolipids influences their ability to participate in the formation of ordered domains, as well as how sphingolipid structure alters ordered domain properties, is described. The diversity of sphingolipid structure is likely to play an important role in modulating the biologically relevant properties of “rafts” in cell membranes.

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Acknowledgement

This work was supported by NIH Grant GM 099892 to E.L.

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  1. Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 11794-5215, USA

    Salvatore Chiantia & Erwin London

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  1. Salvatore Chiantia
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  1. , Department of Molecular Biology, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany

    Erich Gulbins

  2. Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, W. Walnut Street 980, Indianapolis, 46202, Indiana, USA

    Irina Petrache

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Chiantia, S., London, E. (2013). Sphingolipids and Membrane Domains: Recent Advances. In: Gulbins, E., Petrache, I. (eds) Sphingolipids: Basic Science and Drug Development. Handbook of Experimental Pharmacology, vol 215. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1368-4_2

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