• Vicki Myers
  • Laura Rosen
  • Yariv GerberEmail author


Overwhelming epidemiological and pathophysiological evidence has shown that smokers are at significantly increased risk of developing acute coronary syndromes, while those with established cardiovascular disease have lower odds of survival. This chapter discusses the impact of firsthand, secondhand, and thirdhand exposure to tobacco smoke, as well as smokeless tobacco, on the development and progression of cardiovascular disease. Citing numerous examples, we demonstrate the extent of the cardiovascular damage caused not only to smokers themselves but to those around them and the processes by which these changes happen. Smoking is the leading preventable cause of cardiovascular mortality worldwide, making this a crucial issue to address. Strategies to reduce the global burden of tobacco are examined, including smoking cessation and, more controversially, reduction, on both an individual and population level. Biological pathways are reviewed, including atherosclerosis, endothelial dysfunction, and inflammatory processes, and methodological issues in the literature are addressed.


Smoking Cardiovascular disease Secondhand exposure Thirdhand exposure Smoking cessation Smoking reduction Mortality 


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© Springer-Verlag Wien 2013

Authors and Affiliations

  1. 1.Sackler Faculty of Medicine, Department of Epidemiology and Preventive MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Sackler Faculty of Medicine, Department of Health PromotionTel Aviv UniversityTel AvivIsrael
  3. 3.Sackler Faculty of Medicine, Department of Epidemiology and Preventive Medicine, School of Public HealthTel Aviv UniversityTel AvivIsrael

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