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Pathophysiology of the Metabolic Syndrome

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The Metabolic Syndrome

Abstract

The metabolic syndrome is an increasingly prevalent clinical syndrome, closely related to the risk of progression to type 2 diabetes, to cardiovascular disease (CVD) and to several cancers [1–4]. Despite its prevalence (at about 20 % of many western populations and much higher in several high risk populations), it has been a controversial topic since it was first described, largely because of lack of agreement about criteria for definition and diagnosis [5–7]. This has been further compounded by lack of clarity about how the syndrome should be treated. In this chapter, we focus on the pathophysiology of the metabolic syndrome. At the core of this pathophysiology is a gradual and progressive distortion of normal metabolic homeostasis, affecting all of the major metabolically active organs and tissues. Here we will describe these abnormalities in physiology, with the aim of providing a basis on which the treatment of this syndrome can be addressed in a scientifically and medically rational manner.

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Authors and Affiliations

  1. Steno Diabetes Center A/S, Niels Steensens Vej 2-4, 2820, Gentofte, Denmark

    John J. Nolan

  2. Centre for Preventive Medicine, Dublin City University, Health and Human Performance, Dublin 9, Ireland

    Donal J. O’Gorman

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  1. John J. Nolan
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  2. Donal J. O’Gorman
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Correspondence to John J. Nolan .

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Editors and Affiliations

  1. Dept. Endocrinology, Odense University Hospital, Kloevervaenget 6 4, Odense C, 5000, Denmark

    Henning Beck-Nielsen

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Nolan, J.J., O’Gorman, D.J. (2013). Pathophysiology of the Metabolic Syndrome. In: Beck-Nielsen, H. (eds) The Metabolic Syndrome. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1331-8_3

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