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Protein C and Protein S Deficiencies

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Skin Necrosis

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Abstract

Protein C and protein S are vitamin K-dependent protein with natural anticoagulant properties that play a major role in the coagulation pathway. Protein C is activated by the thrombin/thrombomodulin complex. Activated protein C cleaves membrane-bound active factors V and VIII and inactivates them. Protein C inhibitor and α-1 antitrypsin are the main inhibitors of protein C. Protein S is a cofactor of activated protein C and can also directly bond to activated factors V and X.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University Hospital, Besancon, 25000, France

    Sébastien Humbert MD

  2. Department of Dermatology, University Hospital, Besancon, 25000, France

    Philippe Humbert

Authors
  1. Sébastien Humbert MD
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  2. Philippe Humbert
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Corresponding author

Correspondence to Sébastien Humbert MD .

Editor information

Editors and Affiliations

  1. Department of Surgery Pôle EMMBRUN Wound Healing Unit, Montpellier University Hospital, Montpellier, France

    Luc Téot

  2. Department of Geriatrics Wound Healing Unit, Hôpital Rothschild, Paris, France

    Sylvie Meaume MD, PhD

  3. Division of Plastic Surgery, Department of Developmental and Reconstructive Medicine Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

    Sadanori Akita

  4. Division of Vascular Surgery Section of Wound Healing and Tissue, University of Illinois Medical Center, Chicago, IL, USA

    William J. Ennis DO, MBA

  5. Department of Dermatology, Hôpital Erasme Université Libre de Bruxelles, Brussels, Belgium

    Veronique del Marmol

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© 2015 Springer-Verlag Wien

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Humbert, S., Humbert, P. (2015). Protein C and Protein S Deficiencies. In: Téot, L., Meaume, S., Akita, S., Ennis, W.J., del Marmol, V. (eds) Skin Necrosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1241-0_23

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  • DOI: https://doi.org/10.1007/978-3-7091-1241-0_23

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1240-3

  • Online ISBN: 978-3-7091-1241-0

  • eBook Packages: MedicineMedicine (R0)

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