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Retinal Repair Using Stem Cells

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Book cover Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

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Abstract

The retina is the main light-sensing layer of the eye. Degenerations of the retinal cells are leading causes of blindness worldwide. This cellular loss in the mammalian retina is not followed by any appreciable cellular regeneration. In this chapter, we will cover various age-associated retinal degenerations. We will provide evidence of retinal regeneration in nonmammalian systems as well as attempts to rejuvenate stem cell phenotype in mammalian retinas. We will finish with recent work using pluripotent stem cells, both embryonic stem cells as well as induced pluripotent stem cells, to generate new retinal cells for replacement purposes.

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Authors and Affiliations

  1. Department of Biology, Buck Institute for Research on Aging, 8001 Redwood Blvd Rm: 3-234, Novato, CA, 94945, USA

    Mark Gutierrez & Deepak A. Lamba

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  1. Mark Gutierrez
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  2. Deepak A. Lamba
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Correspondence to Deepak A. Lamba .

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Editors and Affiliations

  1. Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Hartmut Geiger

  2. Department of Biology, University of Rochester, Rochester, New York, USA

    Heinrich Jasper

  3. Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Maria Carolina Florian

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Gutierrez, M., Lamba, D.A. (2015). Retinal Repair Using Stem Cells. In: Geiger, H., Jasper, H., Florian, M. (eds) Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1232-8_15

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