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Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures

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Abstract

Various dendrimers can play enormous role in cancer research, diagnosis and treatment. Glycopeptide or peptide dendrimers containing different types of tumor-associated carbohydrate or peptide antigens have been intensively studied for their use as diagnostic or therapeutic tools. Dendrimers possess a great potential that can be utilized in antitumor immunotherapy, either as vaccines or as adjuvants. Further, dendrimeric structures can display direct toxicity against tumor cells, as well as they can serve as carriers for active toxic compounds or vectors for anti/tumor gene therapy thus increasing the therapeutic efficacy and specificity, and simultaneously minimizing adverse effects which limit current therapeutic modalities.

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Authors and Affiliations

  1. Department of Molecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, AS CR, vvi, Prague, Czech Republic

    Jaroslav Šebestík

  2. Institute of Molecular Genetics AS CR, vvi, Prague, Czech Republic

    Milan Reiniš

  3. Laboratory of Glycoconjugates, Institute of Organic Chemistry and Biochemistry, AS CR, vvi, Prague, Czech Republic

    Jan Ježek

Authors
  1. Jaroslav Šebestík
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  2. Milan Reiniš
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  3. Jan Ježek
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© 2012 Springer-Verlag Wien

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Šebestík, J., Reiniš, M., Ježek, J. (2012). Cancer. In: Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1206-9_18

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