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Co-infection with HIV

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Drug Resistance in Leishmania Parasites

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Summary

This chapter describes the epidemiology, current spread and clinical aspects of HIV/Leishmania co-infection and highlights the recently released guidelines of WHO on their management. It discusses the development of resistant Leishmania strains for existing anti-Leishmania drugs and the complexity of chemotherapy for Leishmania/HIV co-infection, which relies on the same drugs that are used in uncomplicated Leishmania. Additionally, prospects for future chemotherapeutic alternatives that target Leishmania and HIV and tackle both infections simultaneously are summarized.

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References

  • Aagaard-Hansen J, Nombela N, Alvar J (2010) Population movement: a key factor in the epidemiology of neglected tropical diseases. Trop Med Int Health 15:1281–1288

    Article  PubMed  Google Scholar 

  • Al-Mohammed HI, Chance ML, Bates PA (2005) Production and characterization of stable amphotericin-resistant amastigotes and promastigotes of Leishmania mexicana. Antimicrob Agents Chemother 49:3274–3280. doi:49/8/3274[pii]10.1128/AAC.49.8.3274-3280.2005

    Article  PubMed  CAS  Google Scholar 

  • Alvar J et al (1997) Leishmania and human immunodeficiency virus co-infection: the first 10 years. Clin Microbiol Rev 10:298–319

    PubMed  CAS  Google Scholar 

  • Alvar J et al (2007) Kala-azar outbreak in Libo Kemkem, Ethiopia: epidemiologic and parasitologic assessment. Am J Trop Med Hyg 77:275–282

    PubMed  Google Scholar 

  • Alvar J et al (2008) The relationship between Leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21:334–359

    Article  PubMed  CAS  Google Scholar 

  • Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78:431–441

    Article  PubMed  CAS  Google Scholar 

  • Bart Ostyn PM et al (2010) Challenges for the implementation of new tools to monitor treatment outcome in Miltefosine-treated Kala-azar patients in India and Nepal. Kaladrug meeting, Antwerp, 2010

    Google Scholar 

  • Bashaye S et al (2009) Risk factors for visceral leishmaniasis in a new epidemic site in Amhara Region, Ethiopia. Am J Trop Med Hyg 81:34–39

    PubMed  Google Scholar 

  • Bentwich Z (2003) Concurrent infections that rise the HIV viral load. J HIV Ther 8(3):72–75

    PubMed  Google Scholar 

  • Bernier R et al (1995) Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani. J Virol 69:7282–7285

    PubMed  CAS  Google Scholar 

  • Carter KC et al (2003) The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis. Antimicrob Agents Chemother 47:1529–1535

    Article  PubMed  CAS  Google Scholar 

  • Cipolla L, La Ferla B, Gregori M (2006) Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitors. Comb Chem High Throughput Screen 9:571–582

    Article  PubMed  CAS  Google Scholar 

  • Cruz I et al (2002) Leishmania in discarded syringes from intravenous drug users. Lancet 359:1124–1125

    Article  PubMed  CAS  Google Scholar 

  • de La Rosa R et al (2002) Incidence of and risk factors for symptomatic visceral leishmaniasis among human immunodeficiency virus type 1-infected patients from Spain in the era of highly active antiretroviral therapy. J Clin Microbiol 40:762–767

    Article  Google Scholar 

  • Decuypere S et al (2005) Gene expression analysis of the mechanism of natural SbV resistance in Leishmania donovani isolates from Nepal. Antimicrob Agents Chemother 49:4616–4621. doi:49/11/4616[pii]10.1128/AAC.49.11.4616-4621.2005

    Article  PubMed  CAS  Google Scholar 

  • del Giudice P et al (2002) Impact of highly active antiretroviral therapy on the incidence of visceral leishmaniasis in a French cohort of patients infected with human immunodeficiency virus. J Infect Dis 186:1366–1370

    Article  PubMed  Google Scholar 

  • Delmas F et al (2004) Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives. Eur J Med Chem 39:685–690

    Article  PubMed  CAS  Google Scholar 

  • Donia M, Hamann MT (2003) Marine natural products and their potential applications as anti-infective agents. Lancet Infect Dis 3:338–348

    Article  PubMed  CAS  Google Scholar 

  • Donia MS et al (2008) Mollamides B and C, Cyclic hexapeptides from the Indonesian tunicate Didemnum molle. J Nat Prod 71:941–945

    Article  PubMed  CAS  Google Scholar 

  • Durand R et al (1998) Leishmania infantum: lack of parasite resistance to Amphotericin-B in a clinically resistant visceral leishmaniasis. Antimicrob Agents Chemother 42:2141–2143

    PubMed  CAS  Google Scholar 

  • Elkhoury A et al (2007) Co-infeccao leishmaniose visceral e AIDS no Brasil. Rev Soc Bras Med Trop 40:124

    Google Scholar 

  • Fakhfakh MA et al (2003) Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections. Bioorg Med Chem 11:5013–5023

    Article  PubMed  CAS  Google Scholar 

  • Gorski S et al (2010) Visceral leishmaniasis relapse in Southern Sudan (1999–2007): a retrospective study of risk factors and trends. PLoS Negl Trop Dis 4:e705. doi:10.1371/journal.pntd.0000705

    Article  PubMed  Google Scholar 

  • Goyeneche-Patino DA et al (2008) Antimony resistance and trypanothione in experimentally selected and clinical strains of Leishmania panamensis. Antimicrob Agents Chemother 52(12):4503–4506. doi: AAC.01075-08[pii]10.1128/AAC.01075-08

    Article  PubMed  CAS  Google Scholar 

  • Gramiccia M, Gradoni L, Orsini S (1992) Decreased sensitivity to meglumine antimoniate (Glucantime) of Leishmania infantum isolated from dogs after several courses of drug treatment. Ann Trop Med Parasitol 86:613–620

    PubMed  CAS  Google Scholar 

  • Grassi F et al (2008) Quinoline compounds decrease in vitro spontaneous proliferation of peripheral blood mononuclear cells (PBMC) from human T-cell lymphotropic virus (HTLV) type-1-infected patients. Biomed Pharmacother 62:430–435

    Article  PubMed  CAS  Google Scholar 

  • Guiguemde RT et al (2003) Leishmania major and HIV co-infection in Burkina Faso. Trans R Soc Trop Med Hyg 97:168–169

    Article  PubMed  Google Scholar 

  • Gul W et al (2006) Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity. Bioorg Med Chem 14:8495–8505

    Article  PubMed  CAS  Google Scholar 

  • Gul W et al (2007) Chemical transformation and biological studies of marine sesquiterpene (S)-(+)-curcuphenol and its analogs. Biochim Biophys Acta 1770:1513–1519

    Article  PubMed  CAS  Google Scholar 

  • Gurubacharya RL et al (2006) Prevalence of visceral Leishmania & HIV co-infection in Nepal. Indian J Med Res 123:473–475

    PubMed  CAS  Google Scholar 

  • Kumar P et al (2010) Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes. PLoS Negl Trop Dis 4:e642. doi:10.1371/journal.pntd.0000642

    Article  PubMed  Google Scholar 

  • Lachaud L et al (2009) Parasite susceptibility to Amphotericin-B in failures of treatment for visceral leishmaniasis in patients co-infected with HIV type 1 and Leishmania infantum. Clin Infect Dis 48:e16–e22. doi:10.1086/595710

    Article  PubMed  CAS  Google Scholar 

  • Laport MS, Santos OC, Muricy G (2009) Marine sponges: potential sources of new antimicrobial drugs. Curr Pharm Biotechnol 10:86–105

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Velez R (2003) The impact of highly active antiretroviral therapy (HAART) on visceral leishmaniasis in Spanish patients who are co-infected with HIV. Ann Trop Med Parasitol 97(Suppl 1):143–147

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Velez R et al (1998) Clinicoepidemiologic characteristics, prognostic factors, and survival analysis of patients co-infected with human immunodeficiency virus and Leishmania in an area of Madrid, Spain. Am J Trop Med Hyg 58:436–443

    PubMed  CAS  Google Scholar 

  • Lyons S, Veeken H, Long J (2003) Visceral leishmaniasis and HIV in Tigray, Ethiopia. Trop Med Int Health 8:733–739

    Article  PubMed  Google Scholar 

  • Maarouf M et al (1998) Development and characterization of paromomycin-resistant Leishmania donovani promastigotes. Parasite 5:167–173

    PubMed  CAS  Google Scholar 

  • Mathur P et al (2006) Visceral leishmaniasis/human immunodeficiency virus co-infection in India: the focus of two epidemics. J Med Microbiol 55:919–922

    Article  PubMed  Google Scholar 

  • Matlashewski G et al (2011) Visceral leishmaniasis: elimination with existing interventions. Lancet Infect Dis 11:322–325

    Article  PubMed  Google Scholar 

  • Mengesha B, Abuhoy M (1978) Kala-azar among labour migrants in Metema-Humera region of Ethiopia. Trop Geogr Med 30:199–206

    PubMed  CAS  Google Scholar 

  • Molina R et al (1999) Infection of sand flies by humans co-infected with Leishmania infantum and human immunodeficiency virus. Am J Trop Med Hyg 60:51–53

    PubMed  CAS  Google Scholar 

  • Moszynski P (2010) Kala-azar outbreak is symptomatic of humanitarian crisis facing southern Sudan. Br Med J 341:c7276. doi: 10.1136/bmj.c7276bmj.c7276[pii]

    Article  Google Scholar 

  • Nakayama H et al (2005) Efficacy of orally administered 2-substituted quinolines in experimental murine cutaneous and visceral leishmaniases. Antimicrob Agents Chemother 49:4950–4956

    Article  PubMed  CAS  Google Scholar 

  • Pettersson S et al (2006) Recent advances in combinatorial chemistry applied to development of anti-HIV drugs. Mini Rev Med Chem 6:91–108

    Article  PubMed  CAS  Google Scholar 

  • Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20:133–163. doi: 20/1/133[pii]10.1128/CMR.00029-06

    Article  PubMed  CAS  Google Scholar 

  • Pintado V et al (2001) Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study. Medicine (Baltimore) 80:54–73

    Article  CAS  Google Scholar 

  • Rao KV et al (2003) New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. J Nat Prod 66:823–828

    Article  PubMed  CAS  Google Scholar 

  • Rao KV et al (2004) Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases. J Nat Prod 67:1314–1318

    Article  PubMed  CAS  Google Scholar 

  • Rao KV et al (2006) Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer’s diseases. J Nat Prod 69:1034–1040

    Article  PubMed  CAS  Google Scholar 

  • Redhu NS et al (2006) Leishmania-HIV co-infection: an emerging problem in India. AIDS 20:1213–1215

    Article  PubMed  Google Scholar 

  • Rijal S et al (2007) Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome? Microbes Infect 9:529–535. doi: S1286-4579(07)00041-X[pii]10.1016/j.micinf.2007.01.009

    Article  PubMed  CAS  Google Scholar 

  • Ritmeijer K et al (2006) A comparison of Miltefosine and sodium stibogluconate for treatment of visceral leishmaniasis in an Ethiopian population with high prevalence of HIV infection. Clin Infect Dis 43:357–364

    Article  PubMed  CAS  Google Scholar 

  • Rosatelli JB et al (1998) Generalized cutaneous leishmaniasis in acquired immunodeficiency syndrome. J Eur Acad Dermatol Venereol 10:229–232. doi: S0926995998000142[pii]

    Article  PubMed  CAS  Google Scholar 

  • Russo R et al (2003) Visceral leishmaniasis in those infected with HIV: clinical aspects and other opportunistic infections. Ann Trop Med Parasitol 97(Suppl 1):99–105

    Article  PubMed  Google Scholar 

  • Sagar S, Kaur M, Minneman KP (2010) Antiviral lead compounds from marine sponges. Mar Drugs 8:2619–2638

    Article  PubMed  CAS  Google Scholar 

  • Saint-Pierre-Chazalet M et al (2009) Membrane sterol depletion impairs Miltefosine action in wild-type and Miltefosine-resistant Leishmania donovani promastigotes. J Antimicrob Chemother 64:993–1001. doi: dkp321[pii]10.1093/jac/dkp321

    Article  PubMed  CAS  Google Scholar 

  • Santos LO et al (2009) HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis. PLoS One 4:e4918. doi:10.1371/journal.pone.0004918

    Article  PubMed  Google Scholar 

  • Savoia D, Allice T, Tovo PA (2005) Antileishmanial activity of HIV protease inhibitors. Int J Antimicrob Agents 26:92–94

    Article  PubMed  CAS  Google Scholar 

  • Seaman J et al (1996) Epidemic visceral leishmaniasis in southern Sudan: treatment of severely debilitated patients under wartime conditions and with limited resources [see comments]. Ann Intern Med 124:664–672

    PubMed  CAS  Google Scholar 

  • Sundar S (2001) Drug resistance in Indian visceral leishmaniasis. Trop Med Int Health 6:849–854. doi:778[pii]

    Article  PubMed  CAS  Google Scholar 

  • Sundar S et al (2011) Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial. Lancet 377:477–486. doi: S0140-6736(10)62050-8[pii]10.1016/S0140-6736(10)62050-8

    Article  PubMed  CAS  Google Scholar 

  • Trudel N et al (2008) Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors. J Infect Dis 198(9):1292–1299. doi:10.1086/592280

    Article  PubMed  CAS  Google Scholar 

  • Tziveleka LA, Vagias C, Roussis V (2003) Natural products with anti-HIV activity from marine organisms. Curr Top Med Chem 3:1512–1535

    Article  PubMed  CAS  Google Scholar 

  • Valdivieso E, Dagger F, Rascon A (2007) Leishmania mexicana: identification and characterization of an aspartyl proteinase activity. Exp Parasitol 116:77–82. doi: S0014-4894(06)00248-7[pii]

    Article  PubMed  CAS  Google Scholar 

  • Valdivieso E et al (2010) Effects of HIV aspartyl-proteinase inhibitors on Leishmania sp. Exp Parasitol 126:557–563. doi: S0014-4894(10)00197-9[pii]10.1016/j.exppara.2010.06.002

    Article  PubMed  CAS  Google Scholar 

  • Vieira NC et al (2008) Selection of the most promising 2-substituted quinoline as antileishmanial candidate for clinical trials. Biomed Pharmacother 62:684–689

    Article  PubMed  CAS  Google Scholar 

  • Watts KR, Tenney K, Crews P (2010) The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules. Curr Opin Biotechnol 21:808–818

    Article  PubMed  CAS  Google Scholar 

  • WHO (2010) WHO Technical Report Series 949

    Google Scholar 

  • World Health Organization Report of the 5th Consultative Meeting on Leishmania/HIV Coinfection (2007) WHO Technical Report Series WHO/CDS/NTD/IDM/2007.5. In, Addis Ababa, Ethiopia, 20–22 Mar 2007. 10.1016/j.exppara.2006.10.006

  • Yu D, Morris-Natschke SL, Lee KH (2007) New developments in natural products-based anti-AIDS research. Med Res Rev 27:108–132

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The Spanish Agency for International Cooperation for Development is supporting the WHO Leishmaniasis program and is focused among other activities on the treatment of HIV-Leishmania co-infected patients in Ethiopia. LR is supported by grants from EU HEALTH-2007-223414 and Fondo de Investigación Sanitaria RETICS RD06-0021-06 and PS09/01928.

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Authors and Affiliations

  1. Department of Neglected Tropical Diseases, World Health Organization, 20, Avenue Appia, CH-1211, Geneva 27, Switzerland

    Margriet den Boer & Jorge Alvar

  2. Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu, 9, 28040, Madrid, Spain

    Luis Rivas

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  1. Margriet den Boer
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  2. Luis Rivas
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  3. Jorge Alvar
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Correspondence to Jorge Alvar .

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Editors and Affiliations

  1. Fac. Medicina, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, 1062, Venezuela

    Alicia Ponte-Sucre

  2. Universidad Central de Venezuela, ciudad universitaria, Caracas, 1062, Venezuela

    Emilia Diaz

  3. Universidad Central de Venezuela, ciudad universitaria, Caracas, 1062, Venezuela

    Maritza Padrón-Nieves

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den Boer, M., Rivas, L., Alvar, J. (2013). Co-infection with HIV. In: Ponte-Sucre, A., Diaz, E., Padrón-Nieves, M. (eds) Drug Resistance in Leishmania Parasites. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1125-3_8

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  • DOI: https://doi.org/10.1007/978-3-7091-1125-3_8

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